Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 10/20 | 0.58 |
| ▸ | GSK3A | P49840 | 2/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.48 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.48 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HAT1 | O14929 | 1/20 | 0.44 |
| ▸ | EP300 | Q09472 | 1/20 | 0.44 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4498312 | 0.93 | GSK3B (0.49) | GSK3BGSK3AFGFR1FGFR2FGFR3 | |
| SCHEMBL4491583 | 0.87 | GSK3B (0.53) | GSK3BGSK3AFGFR1FGFR2FGFR3 | |
| SCHEMBL4493437 | 0.87 | HDAC6 (0.54) | GSK3BGSK3AFGFR1FGFR2FGFR3 | |
| SCHEMBL4486679 | 0.86 | GSK3B (0.64) | GSK3BGSK3AFGFR1FGFR2FGFR3 | |
| SCHEMBL4479666 | 0.86 | GSK3B (0.58) | GSK3BGSK3AFGFR1FGFR2FGFR3 | |
| SCHEMBL4502553 | 0.85 | HDAC6 (0.55) | GSK3BGSK3AFGFR1FGFR2FGFR3 | |
| SCHEMBL4503236 | 0.85 | GSK3B (0.50) | GSK3BGSK3AFGFR1FGFR2FGFR3 | |
| SCHEMBL4493566 | 0.85 | HDAC6 (0.54) | GSK3BGSK3AFGFR1FGFR2FGFR3 | |
| SCHEMBL4476038 | 0.85 | GSK3B (0.52) | GSK3BGSK3AFGFR1FGFR2FGFR3 | |
| SCHEMBL4496026 | 0.85 | GSK3B (0.49) | GSK3BGSK3AFGFR1FGFR2FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |