Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 5/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.52 |
| ▸ | FGFR4 | P22455 | 4/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | GSK3A | P49840 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4482482 | 0.89 | HDAC6 (0.57) | GSK3BHDAC6FGFR4KDRHDAC1 | |
| SCHEMBL4498046 | 0.89 | HDAC6 (0.57) | GSK3BHDAC6FGFR4GSK3AKDR | |
| SCHEMBL4483627 | 0.88 | GSK3B (0.54) | GSK3BHDAC6FGFR4CYP1A2GSK3A | |
| SCHEMBL4491565 | 0.86 | HDAC6 (0.49) | GSK3BHDAC6FGFR4CYP1A2KDR | |
| SCHEMBL4503270 | 0.86 | GSK3B (0.56) | GSK3BHDAC6FGFR4CYP1A2GSK3A | |
| SCHEMBL4499750 | 0.86 | HDAC6 (0.64) | GSK3BHDAC6FGFR4CYP1A2GSK3A | |
| SCHEMBL4495002 | 0.86 | GSK3B (0.69) | GSK3BHDAC6FGFR4CYP1A2GSK3A | |
| SCHEMBL4493662 | 0.84 | GSK3B (0.63) | GSK3BHDAC6CYP1A2GSK3A | |
| SCHEMBL4484175 | 0.84 | HDAC6 (0.52) | GSK3BHDAC6FGFR4CYP1A2GSK3A | |
| SCHEMBL4481624 | 0.84 | HDAC6 (0.56) | GSK3BHDAC6FGFR4GSK3AHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |