Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR2 | P21802 | 6/20 | 0.58 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.58 |
| ▸ | FGFR4 | P22455 | 5/20 | 0.58 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.57 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | CDC7 | O00311 | 1/20 | 0.48 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | PAK4 | O96013 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.48 |
| ▸ | CDK8 | P49336 | 1/20 | 0.48 |
| ▸ | CLK2 | P49760 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | CDK7 | P50613 | 1/20 | 0.48 |
| ▸ | CDK9 | P50750 | 1/20 | 0.48 |
| ▸ | PRKX | P51817 | 1/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4500976 | 0.94 | HDAC6 (0.58) | FGFR2FGFR1FGFR4FGFR3HDAC6 | |
| SCHEMBL4497298 | 0.91 | HDAC6 (0.71) | FGFR2FGFR1FGFR4FGFR3HDAC6 | |
| SCHEMBL4483944 | 0.89 | HDAC6 (0.55) | FGFR2FGFR1FGFR4FGFR3HDAC6 | |
| SCHEMBL4493101 | 0.87 | HDAC6 (0.70) | FGFR2FGFR1FGFR4FGFR3HDAC6 | |
| SCHEMBL4483350 | 0.87 | FGFR2 (0.65) | FGFR2FGFR1FGFR4FGFR3HDAC6 | |
| SCHEMBL4488644 | 0.83 | HDAC6 (0.64) | FGFR2FGFR1FGFR4FGFR3HDAC6 | |
| SCHEMBL4503504 | 0.82 | HDAC6 (0.58) | FGFR2FGFR1FGFR4FGFR3HDAC6 | |
| SCHEMBL4494678 | 0.82 | HDAC6 (0.68) | FGFR2FGFR1FGFR4FGFR3HDAC6 | |
| SCHEMBL4498018 | 0.82 | FGFR2 (0.53) | FGFR2FGFR1FGFR4FGFR3HDAC6 | |
| SCHEMBL4484006 | 0.81 | HDAC6 (0.61) | FGFR2FGFR1FGFR4FGFR3HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |