Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 11/20 | 0.47 |
| ▸ | JAK1 | P23458 | 11/20 | 0.47 |
| ▸ | JAK3 | P52333 | 11/20 | 0.47 |
| ▸ | TYK2 | P29597 | 10/20 | 0.47 |
| ▸ | ALK | Q9UM73 | 12/20 | 0.44 |
| ▸ | STK4 | Q13043 | 1/20 | 0.34 |
| ▸ | STK3 | Q13188 | 1/20 | 0.34 |
| ▸ | STK26 | Q9P289 | 1/20 | 0.34 |
| ▸ | STK24 | Q9Y6E0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL1076384 | 0.95 | JAK2 (0.42) | JAK2JAK1JAK3TYK2ALK | |
| SCHEMBL13623234 | 0.94 | JAK2 (0.44) | JAK2JAK1JAK3TYK2ALK | |
| SCHEMBL13623230 | 0.94 | JAK2 (0.44) | JAK2JAK1JAK3TYK2ALK | |
| SCHEMBL1075074 | 0.94 | JAK2 (0.44) | JAK2JAK1JAK3TYK2ALK | |
| SCHEMBL4363327 | 0.92 | JAK2 (0.43) | JAK2JAK1JAK3TYK2ALK | |
| SCHEMBL1074027 | 0.92 | JAK2 (0.43) | JAK2JAK1JAK3TYK2ALK | |
| SCHEMBL1073047 | 0.92 | JAK2 (0.45) | JAK2JAK1JAK3TYK2ALK | |
| Trifluoroacetic Acid SCHEMBL1075303 | 0.89 | JAK2 (0.41) | JAK2JAK1JAK3TYK2ALK | |
| Trifluoroacetic Acid SCHEMBL4352924 | 0.89 | JAK2 (0.41) | JAK2JAK1JAK3TYK2ALK | |
| Trifluoroacetic Acid SCHEMBL1075853 | 0.89 | JAK2 (0.41) | JAK2JAK1JAK3TYK2ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009132202-A2 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2009-10-29 | — | — | WO | disclosed |