Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.56 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.48 |
| ▸ | GSK3B | P49841 | 5/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.47 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | GSK3A | P49840 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4480882 | 0.92 | GSK3B (0.59) | HDAC6HDAC1HDAC2HDAC8FGFR4 | |
| SCHEMBL4505048 | 0.92 | GSK3B (0.49) | HDAC6HDAC1HDAC2HDAC8FGFR4 | |
| SCHEMBL4487636 | 0.89 | HDAC6 (0.52) | HDAC6GSK3BFGFR1FGFR2FGFR3 | |
| SCHEMBL4503333 | 0.88 | GSK3B (0.58) | HDAC6HDAC1HDAC2HDAC8GSK3B | |
| SCHEMBL4496312 | 0.88 | GSK3B (0.60) | HDAC6HDAC1HDAC2HDAC8GSK3B | |
| SCHEMBL4502109 | 0.87 | HDAC6 (0.63) | HDAC6HDAC1HDAC2HDAC8FGFR4 | |
| SCHEMBL4486296 | 0.87 | HDAC6 (0.49) | HDAC6GSK3BFGFR1FGFR2FGFR3 | |
| SCHEMBL4496491 | 0.87 | HDAC6 (0.47) | HDAC6HDAC1HDAC2HDAC8GSK3B | |
| SCHEMBL4485505 | 0.86 | GSK3B (0.59) | HDAC6HDAC1HDAC2HDAC8GSK3B | |
| SCHEMBL4503997 | 0.85 | HDAC6 (0.63) | HDAC6HDAC1HDAC2HDAC8FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |