⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9579055 | 0.74 | — | — | |
| SCHEMBL12472456 | 0.74 | — | — | |
| SCHEMBL20206782 | 0.72 | — | — | |
| SCHEMBL16736442 | 0.71 | CRBN (0.35) | — | |
| SCHEMBL12213891 | 0.67 | — | — | |
| SCHEMBL14072021 | 0.67 | — | — | |
| SCHEMBL10591826 | 0.67 | — | — | |
| SCHEMBL11001085 | 0.67 | — | — | |
| SCHEMBL14315764 | 0.65 | CRBN (0.42) | — | |
| SCHEMBL14075349 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 102 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11639355-B2 | Substituted pyrrolo[3,4-d]imidazoles as MDM2-p53 inhibitors | Luoxin Pharmaceutical (Shanghai) Co., Ltd. (CN) | 2023-05-02 | — | — | US | disclosed |
| US-11639355-B2 | Substituted pyrrolo[3,4-d]imidazoles as MDM2-p53 inhibitors | Luoxin Pharmaceutical (Shanghai) Co., Ltd. (CN) | 2023-05-02 | — | — | US | disclosed |
| EP-3692040-B1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2022-12-28 | — | — | EP | disclosed |
| WO-2019154380-A1 | KYNURENINE PATHWAY INHIBITOR | 南京明德新药研发股份有限公司 | 2019-08-15 | — | — | WO | disclosed |
| WO-2019149244-A1 | JAK INHIBITOR AND USE THEREOF | 南京明德新药研发股份有限公司 | 2019-08-08 | — | — | WO | disclosed |
| WO-2019141250-A1 | PYRIDONE-PYRIMIDINE DERIVATIVE ACTING AS KRASG12C MUTEIN INHIBITOR | 南京明德新药研发股份有限公司 | 2019-07-25 | — | — | WO | disclosed |
| US-9334245-B2 | Neprilysin inhibitors | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2016-05-10 | — | — | US | disclosed |
| US-8912208-B2 | (4-{4-[5-(benzooxazol-2-ylamino)-pyridin-2-yl]-phenyl}-cyclohexyl)-acetic acid useful for treating or preventing conditions or disorders associated with DGAT1 activity | NOVARTIS AG (CH) | 2014-12-16 | — | — | US | disclosed |
| US-20130018054-A1 | NEW COMPOUNDS | NOVARTIS AG (CH) | 2013-01-17 | — | — | US | disclosed |
| EP-1086950-B1 | HETEROCYCLIC INDOLE DERIVATIVES AND MONO- OR DIAZAINDOLE DERIVATIVES | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2010-09-29 | — | — | EP | disclosed |
| US-20040192936-A1 | PRODUCTION OF N-ARYL-2-LACTAM AND N-ALKYL-2-LACTAM BY REDUCTIVE AMINATION OF LACTONES WITH ARYL AND ALKYL NITRO COMPOUNDS | E. I. DU PONT DE NEMOURS AND COMPANY | 2004-09-30 | — | — | US | disclosed |
| US-20040192932-A1 | Production of N-(methyl aryl)-2-lactam, N-(Methyl cycloalkyl)-2-lactam and N-alkyl-2-lactam by reductive amination of lactones with aryl and alkyl cyano compounds | E.I. DU PONT NEMOURS AND COMPANY | 2004-09-30 | — | — | US | disclosed |
| US-20040192937-A1 | PRODUCTION OF N-ARYL-2-LACTAM AND N-CYCLOALKYL-2-LACTAM BY REDUCTIVE AMINATION OF LACTONES WITH ARYL AMINES | E. I. DU PONT DE NEMOURS AND COMPANY | 2004-09-30 | — | — | US | disclosed |
| US-20040192939-A1 | Production of 5-methyl-N-aryl-2-pyrrolidone and 5-methyl-N-cycloalkyl-2-pyrrolidone by reductive amination of levulinic acid with aryl amines | MANZER LEO ERNEST (US) | 2004-09-30 | — | — | US | disclosed |
| US-20040192935-A1 | Production of 5-methyl-N-(methyl aryl)-2-pyrrolidone, 5-methyl-N-(methyl cycloalkyl)-2-pyrrolidone and 5-methyl-N-alkyl-2-pyrrolidone by reductive amination of levulinic acid esters with cyano compounds | E.I. DU PONT DE NEMOURS AND COMPANY | 2004-09-30 | — | — | US | disclosed |
| US-6743819-B1 | METAL CATALYST | E. I. DU PONTE DE NEMOURS AND COMPANY | 2004-06-01 | — | — | US | disclosed |
| EP-0666729-A1 | COSMETIC COMPOSITION | UNILEVER PLC (GB) | 1995-08-16 | — | — | EP | disclosed |
| WO-1994009750-A1 | COSMETIC COMPOSITION | UNILEVER PLC (GB) | 1994-05-11 | — | — | WO | disclosed |
| EP-0008916-A1 | Compositions for treating used rubber and their use in a recycling process | SIXTH WAKOOL PTY. LTD. (AU) | 1980-03-19 | — | — | EP | disclosed |
| US-3951769-A | Epoxide photopolymerizable compositions containing cyclic amides as gelation inhibitor and methods of polymerizing | AMERICAN CAN COMPANY (US) | 1976-04-20 | — | — | US | disclosed |