Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.74 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.74 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.74 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.72 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.72 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.72 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.69 |
| ▸ | GSK3A | P49840 | 4/20 | 0.69 |
| ▸ | GSK3B | P49841 | 4/20 | 0.69 |
| ▸ | AAK1 | Q2M2I8 | 13/20 | 0.69 |
| ▸ | GAK | O14976 | 4/20 | 0.64 |
| ▸ | STK16 | O75716 | 4/20 | 0.64 |
| ▸ | BMP2K | Q9NSY1 | 4/20 | 0.64 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.63 |
| ▸ | PIM1 | P11309 | 1/20 | 0.63 |
| ▸ | CDK2 | P24941 | 1/20 | 0.63 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.62 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.62 |
| ▸ | CDKL2 | Q92772 | 1/20 | 0.62 |
| ▸ | RIOK1 | Q9BRS2 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4502345 | 0.96 | FGFR1 (0.69) | HDAC1HDAC2HDAC8FGFR1FGFR2 | |
| SCHEMBL4504749 | 0.96 | FGFR1 (0.69) | HDAC1HDAC2HDAC8FGFR1FGFR2 | |
| SCHEMBL4490399 | 0.89 | HDAC1 (0.92) | HDAC1HDAC2HDAC8HDAC6GSK3A | |
| SCHEMBL4491665 | 0.85 | HDAC1 (0.67) | HDAC1HDAC2HDAC8FGFR1FGFR2 | |
| SCHEMBL4483420 | 0.84 | HDAC1 (0.74) | HDAC1HDAC2HDAC8FGFR1FGFR2 | |
| SCHEMBL4493792 | 0.84 | FGFR1 (0.73) | HDAC1HDAC2HDAC8FGFR1FGFR2 | |
| SCHEMBL4485572 | 0.84 | HDAC1 (0.85) | HDAC1HDAC2HDAC8HDAC6GSK3A | |
| SCHEMBL4481656 | 0.84 | HDAC1 (0.85) | HDAC1HDAC2HDAC8HDAC6GSK3A | |
| SCHEMBL12293068 | 0.84 | AAK1 (0.73) | HDAC1HDAC2HDAC8GSK3AGSK3B | |
| SCHEMBL4493075 | 0.84 | HDAC1 (0.70) | HDAC1HDAC2HDAC8FGFR1FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |