Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 14/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | GSK3A | P49840 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4490560 | 0.86 | HDAC1 (0.64) | GSK3BHDAC1HDAC2HDAC8AURKA | |
| SCHEMBL4490672 | 0.83 | GSK3B (0.74) | GSK3BCYP1A2 | |
| SCHEMBL4484379 | 0.82 | GSK3B (0.58) | GSK3BHDAC1HDAC2HDAC8 | |
| SCHEMBL4484894 | 0.82 | GSK3B (0.53) | GSK3BAURKAAURKBCYP1A2CDK2 | |
| SCHEMBL4502111 | 0.82 | GSK3B (0.57) | GSK3BAURKAAURKBCYP1A2CDK2 | |
| SCHEMBL4480311 | 0.81 | GSK3B (0.56) | GSK3BHDAC1HDAC2HDAC8CYP1A2 | |
| SCHEMBL4488982 | 0.81 | POLB (0.52) | GSK3BAURKAAURKBCYP1A2CDK2 | |
| SCHEMBL4498920 | 0.81 | HDAC1 (0.54) | GSK3BHDAC1HDAC2HDAC8 | |
| SCHEMBL4487296 | 0.80 | GSK3B (0.60) | GSK3BHDAC1HDAC2HDAC8 | |
| SCHEMBL4487777 | 0.80 | GSK3B (0.68) | GSK3BHDAC1HDAC2HDAC8CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |