Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 18/20 | 0.73 |
| ▸ | RAF1 | P04049 | 10/20 | 0.44 |
| ▸ | IKBKB | O14920 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4483912 | 1.00 | BRAF (0.73) | BRAFRAF1IKBKBEGFR | |
| SCHEMBL3819000 | 0.93 | BRAF (0.77) | BRAFRAF1IKBKB | |
| SCHEMBL3808685 | 0.92 | BRAF (0.66) | BRAFRAF1EGFR | |
| SCHEMBL13838935 | 0.92 | BRAF (0.66) | BRAFRAF1EGFR | |
| SCHEMBL3808687 | 0.92 | BRAF (0.66) | BRAFRAF1EGFR | |
| SCHEMBL14340205 | 0.92 | BRAF (0.86) | BRAFRAF1IKBKB | |
| SCHEMBL3810791 | 0.91 | BRAF (0.78) | BRAFRAF1 | |
| SCHEMBL3810973 | 0.91 | BRAF (0.77) | BRAFRAF1IKBKB | |
| SCHEMBL2745808 | 0.90 | BRAF (0.80) | BRAFRAF1IKBKB | |
| SCHEMBL3817771 | 0.89 | BRAF (0.74) | BRAFRAF1IKBKBEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090136499-A1 | RAF Inhibitors and Uses Thereof | ARQULE, INC. (US) | 2009-05-28 | — | — | US | disclosed |
| US-20090136499-A1 | RAF Inhibitors and Uses Thereof | ARQULE, INC. (US) | 2009-05-28 | — | — | US | disclosed |
| US-7501430-B2 | e.g. 3-{5-[2-({(3R)-1-[(4-chlorophenyl)sulfonyl]piperidin-3-yl}amino)pyrimidin-4-yl]imidazo[2,1-b][1,3]thiazol-6-yl}phenyl carbamate; antiproliferative, anticarcinogenic agent; cell proliferative disorders | ARQULE, INC. (US) | 2009-03-10 | — | — | US | disclosed |
| US-20070281955-A1 | RAF inhibitors and their uses | ARQULE, INC. | 2007-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070281955-A1 | RAF inhibitors and their uses | BRAF, RAF1, ARAF | BRAF 1/4885RAF1 2/4885IKBKB 421/4885 |
| US-20090136499-A1 | RAF Inhibitors and Uses Thereof | BRAF, RAF1, ARAF | BRAF 1/4885RAF1 2/4885IKBKB 422/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.