Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 3/20 | 0.55 |
| ▸ | WEE1 | P30291 | 3/20 | 0.55 |
| ▸ | EGFR | P00533 | 4/20 | 0.55 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.48 |
| ▸ | CCNK | O75909 | 1/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | CCND3 | P30281 | 1/20 | 0.48 |
| ▸ | CDK9 | P50750 | 1/20 | 0.48 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 2/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | ULK1 | O75385 | 2/20 | 0.43 |
| ▸ | CTSC | P53634 | 1/20 | 0.42 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4483955 | 1.00 | ALK (0.55) | ALKWEE1EGFRPTK2CCNK | |
| SCHEMBL4485141 | 0.92 | EGFR (0.53) | ALKEGFRPTK2CCNKCCNA2 | |
| SCHEMBL4485146 | 0.92 | EGFR (0.53) | ALKEGFRPTK2CCNKCCNA2 | |
| SCHEMBL4483048 | 0.92 | EGFR (0.46) | ALKWEE1EGFRPTK2CCNK | |
| SCHEMBL4483052 | 0.92 | EGFR (0.46) | ALKWEE1EGFRPTK2CCNK | |
| SCHEMBL4480396 | 0.90 | PTK2 (0.47) | ALKWEE1EGFRPTK2CDK9 | |
| SCHEMBL4480403 | 0.90 | PTK2 (0.47) | ALKWEE1EGFRPTK2CDK9 | |
| SCHEMBL4486780 | 0.86 | WEE1 (0.56) | ALKWEE1EGFRPTK2CCNK | |
| SCHEMBL4483272 | 0.85 | WEE1 (0.52) | ALKWEE1EGFRPTK2CCNK | |
| SCHEMBL4479464 | 0.81 | WEE1 (0.56) | ALKWEE1EGFRPTK2CCNK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1989198-B1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES FOR THE TREATMENT AND/OR PREVENTION OF CANCER, INFECTIONS, INFLAMMATORY AND AUTOIMMUNE DISORDERS | BOEHRINGER INGELHEIM INT (DE) | 2013-10-09 | — | — | EP | claimed |
| US-7569561-B2 | 2,4-diaminopyrimidines useful for treating cell proliferation diseases | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-08-04 | — | — | US | claimed |
| US-20070207999-A1 | New Compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-09-06 | — | — | US | claimed |
| US-7569561-B2 | 2,4-diaminopyrimidines useful for treating cell proliferation diseases | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-08-04 | — | — | US | disclosed |
| US-20070207999-A1 | New Compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-09-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070207999-A1 | New Compounds | CCNA1, MKI67, CCNT1 | ALK 3068/4885WEE1 483/4885EGFR 280/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.