Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 12/20 | 0.82 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.82 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.82 |
| ▸ | DRD2 | P14416 | 8/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.49 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.49 |
| ▸ | DRD4 | P21917 | 3/20 | 0.49 |
| ▸ | DRD3 | P35462 | 3/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.48 |
| ▸ | HTR2A | P28223 | 3/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.48 |
| ▸ | KMO | O15229 | 1/20 | 0.43 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4099093 | 0.92 | CHRM1 (0.79) | CHRM1CHRM5CHRM3DRD2CHRM2 | |
| SCHEMBL4101669 | 0.92 | CHRM1 (0.85) | CHRM1CHRM5CHRM3DRD2CHRM2 | |
| SCHEMBL4472194 | 0.91 | CHRM1 (0.68) | CHRM1CHRM5CHRM3DRD2CHRM2 | |
| SCHEMBL29400529 | 0.90 | CHRM1 (1.00) | CHRM1CHRM5CHRM3DRD2CHRM2 | |
| SCHEMBL4069821 | 0.90 | CHRM1 (1.00) | CHRM1CHRM5CHRM3DRD2CHRM2 | |
| SCHEMBL6437500 | 0.88 | CHRM1 (0.96) | CHRM1CHRM5CHRM3DRD2CHRM2 | |
| SCHEMBL4098138 | 0.82 | CHRM1 (0.80) | CHRM1CHRM5CHRM3DRD2CHRM2 | |
| SCHEMBL4091518 | 0.82 | CHRM1 (0.71) | CHRM1CHRM5CHRM3DRD2CHRM2 | |
| SCHEMBL4104781 | 0.81 | CHRM1 (0.74) | CHRM1CHRM5CHRM3DRD2CHRM2 | |
| SCHEMBL4108082 | 0.80 | CHRM1 (0.68) | CHRM1CHRM5CHRM3DRD2CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7576100-B2 | Muscarinic agonists | ACADIA PHARMACEUTICALS, INC. (US) | 2009-08-18 | — | — | US | disclosed |