Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.70 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.61 |
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | MITF | O75030 | 1/20 | 0.54 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.53 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.53 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.53 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.52 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | EEF2K | O00418 | 1/20 | 0.52 |
| ▸ | PLK4 | O00444 | 1/20 | 0.52 |
| ▸ | PIM1 | P11309 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4484519 | 1.00 | MAOB (0.70) | MAOBMCL1KDM4ELMNAGAA | |
| SCHEMBL4477433 | 0.92 | MAOB (0.77) | MAOBMCL1KDM4ELMNAGAA | |
| SCHEMBL4477440 | 0.92 | MAOB (0.77) | MAOBMCL1KDM4ELMNAGAA | |
| SCHEMBL6028906 | 0.90 | MAOB (0.71) | MAOBMCL1KDM4ELMNAMAPT | |
| SCHEMBL4487344 | 0.90 | MAOB (0.71) | MAOBMCL1KDM4ELMNAMAPT | |
| SCHEMBL4489692 | 0.90 | MCL1 (0.70) | MAOBMCL1KDM4ELMNAGAA | |
| SCHEMBL4489689 | 0.90 | MCL1 (0.70) | MAOBMCL1KDM4ELMNAGAA | |
| SCHEMBL3436925 | 0.88 | MAOB (0.71) | MAOBMCL1KDM4ELMNAGAA | |
| SCHEMBL13678222 | 0.88 | MAOB (0.68) | MAOBMCL1KDM4ELMNAGAA | |
| SCHEMBL4487377 | 0.85 | MAOB (0.70) | MAOBMCL1KDM4ELMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1272457-B9 | COMPOUNDS FOR MODULATING CELL PROLIFERATION | HSC RES DEV LP (CA) | 2006-12-20 | — | — | EP | claimed |
| EP-1272457-B1 | COMPOUNDS FOR MODULATING CELL PROLIFERATION | HSC RES DEV LP (CA) | 2006-08-23 | — | — | EP | claimed |
| US-7012095-B2 | Compounds for modulating cell proliferation | HSC RESEARCH AND DEVELOPMENT LIMITED (CA) | 2006-03-14 | — | — | US | claimed |
| US-7598419-B2 | Compounds for modulating cell proliferation | HSC RESEARCH AND DEVELOPMENT LIMITED PARTNERSHIP (CA) | 2009-10-06 | — | — | US | disclosed |
| US-7598419-B2 | Compounds for modulating cell proliferation | HSC RESEARCH AND DEVELOPMENT LIMITED PARTNERSHIP (CA) | 2009-10-06 | — | — | US | disclosed |
| US-7598419-B2 | Compounds for modulating cell proliferation | HSC RESEARCH AND DEVELOPMENT LIMITED PARTNERSHIP (CA) | 2009-10-06 | — | — | US | disclosed |
| US-20070243612-A1 | Novel Compounds for Modulating Cell Proliferation | HSC RESEARCH AND DEVELOPMENT LIMITED PARTNERSHIP (CA) | 2007-10-18 | — | — | US | disclosed |
| US-20070243612-A1 | Novel Compounds for Modulating Cell Proliferation | HSC RESEARCH AND DEVELOPMENT LIMITED PARTNERSHIP (CA) | 2007-10-18 | — | — | US | disclosed |
| US-20070243612-A1 | Novel Compounds for Modulating Cell Proliferation | HSC RESEARCH AND DEVELOPMENT LIMITED PARTNERSHIP (CA) | 2007-10-18 | — | — | US | disclosed |
| EP-1727822-A4 | NOVEL COMPOUNDS FOR MODULATING CELL PROLIFERATION | HSC RES DEV LP (CA) | 2007-05-09 | — | — | EP | disclosed |
| WO-2007006143-A1 | COMPOSITIONS AND METHODS FOR DETECTING TRANSFORMED CELLS | THE HOSPITAL FOR SICK CHILDREN (CA) | 2007-01-18 | — | — | WO | disclosed |
| EP-1272457-B9 | COMPOUNDS FOR MODULATING CELL PROLIFERATION | HSC RES DEV LP (CA) | 2006-12-20 | — | — | EP | disclosed |
| EP-1727822-A1 | NOVEL COMPOUNDS FOR MODULATING CELL PROLIFERATION | HSC Research and Development Limited Partnership (CA) | 2006-12-06 | — | — | EP | disclosed |
| US-20060241084-A1 | Inhibition of vascular endothelial growth factor | THE HOSPITAL FOR SICK CHILDREN (CA) | 2006-10-26 | — | — | US | disclosed |
| EP-1272457-B1 | COMPOUNDS FOR MODULATING CELL PROLIFERATION | HSC RES DEV LP (CA) | 2006-08-23 | — | — | EP | disclosed |
| WO-2005092904-A1 | NOVEL COMPOUNDS FOR MODULATING CELL PROLIFERATION | HSC RESEARCH AND DEVELOPMENT LIMITED PARTNERSHIP (CA) | 2005-10-06 | — | — | WO | disclosed |
| US-20050014690-A1 | Styryl acrylonitrile compounds and their use to promote myelopoiesis | THE HOSPITAL FOR SICK CHILDREN (CA) | 2005-01-20 | — | — | US | disclosed |
| US-6800659-B2 | NOVEL STYRYLACRYLONITRILE COMPOUNDS WHICH ARE USEFUL IN TREATING A VARIETY OF CELL PROLIFERATIVE DISORDERS SUCH AS CANCER ARE DISCLOSED. A METHOD OF MODULATING CELL PROLIFERATION COMPRISING ADMINISTERING AN EFFECTIVE AMOUNT OF | HSC RESEARCH AND DEVELOPMENT LIMITED PARTNERSHIP (CA) | 2004-10-05 | — | — | US | disclosed |
| EP-1453500-A1 | STYRYL ACRYLONITRILE COMPOUNDS AND THEIR USE TO PROMOTE MYELOPOIESIS | THE HOSPITAL FOR SICK CHILDREN (CA) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003030895-A1 | STYRYL ACRYLONITRILE COMPOUNDS AND THEIR USE TO PROMOTE MYELOPOIESIS | THE HOSPITAL FOR SICK CHILDREN (CA) | 2003-04-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060241084-A1 | Inhibition of vascular endothelial growth factor | VEGFA, FLT4, FLT1 | MAOB 495/4885MCL1 1303/4885KDM4E 3163/4885 |
| US-20070243612-A1 | Novel Compounds for Modulating Cell Proliferation | MKI67, CCNA1, PCNA | MAOB 3511/4885MCL1 7/4885KDM4E 3095/4885 |
| US-20050014690-A1 | Styryl acrylonitrile compounds and their use to promote myelopoiesis | MCL1, MYD88, MYADM | MAOB 3016/4885MCL1 1/4885KDM4E 3886/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.