Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 14/20 | 0.75 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.54 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4498585 | 0.92 | GSK3B (0.64) | GSK3BKCNQ3KCNQ2HDAC1HDAC2 | |
| SCHEMBL4505755 | 0.89 | HDAC1 (0.68) | GSK3BHDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL4487872 | 0.87 | GSK3B (0.71) | GSK3BHDAC1HDAC2HDAC8CYP1A2 | |
| SCHEMBL4479144 | 0.86 | GSK3B (0.71) | GSK3BHDAC1HDAC2HDAC8CYP1A2 | |
| SCHEMBL1461479 | 0.86 | GSK3B (1.00) | GSK3BCYP1A2 | |
| SCHEMBL4488133 | 0.85 | GSK3B (0.67) | GSK3BHDAC1HDAC2HDAC8 | |
| SCHEMBL4503133 | 0.85 | GSK3B (0.70) | GSK3BHDAC1HDAC2HDAC8CYP1A2 | |
| SCHEMBL4493309 | 0.83 | HDAC6 (0.63) | GSK3BHDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL4492678 | 0.83 | GSK3B (0.67) | GSK3BHDAC1HDAC2HDAC8 | |
| SCHEMBL4503403 | 0.83 | GSK3B (0.70) | GSK3BHDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |