Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.76 |
| ▸ | KIT | P10721 | 10/20 | 0.76 |
| ▸ | FLT3 | P36888 | 10/20 | 0.76 |
| ▸ | PLK4 | O00444 | 8/20 | 0.65 |
| ▸ | MAP4K4 | O95819 | 8/20 | 0.65 |
| ▸ | MARK3 | P27448 | 8/20 | 0.65 |
| ▸ | AXL | P30530 | 8/20 | 0.65 |
| ▸ | MAP4K2 | Q12851 | 8/20 | 0.65 |
| ▸ | STK3 | Q13188 | 8/20 | 0.65 |
| ▸ | SLK | Q9H2G2 | 8/20 | 0.65 |
| ▸ | MKNK2 | Q9HBH9 | 8/20 | 0.65 |
| ▸ | LCK | P06239 | 8/20 | 0.65 |
| ▸ | LIMK1 | P53667 | 7/20 | 0.65 |
| ▸ | MARK2 | Q7KZI7 | 7/20 | 0.65 |
| ▸ | CLK4 | Q9HAZ1 | 7/20 | 0.65 |
| ▸ | AURKA | O14965 | 7/20 | 0.65 |
| ▸ | BLK | P51451 | 7/20 | 0.65 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.65 |
| ▸ | PLK3 | Q9H4B4 | 6/20 | 0.65 |
| ▸ | RPS6KA3 | P51812 | 6/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4463114 | 0.90 | KDR (0.76) | KDRKITFLT3PLK4MAP4K4 | |
| SCHEMBL4470826 | 0.88 | KIT (0.83) | KDRKITFLT3PLK4MAP4K4 | |
| SCHEMBL4470159 | 0.86 | KDR (1.00) | KDRKITFLT3PLK4MAP4K4 | |
| SCHEMBL4477134 | 0.86 | KDR (0.76) | KDRKITFLT3PLK4MAP4K4 | |
| SCHEMBL4471717 | 0.84 | KDR (0.83) | KDRKITFLT3PLK4MAP4K4 | |
| SCHEMBL4466621 | 0.82 | KDR (0.79) | KDRKITFLT3PLK4MAP4K4 | |
| SCHEMBL4489560 | 0.81 | KDR (0.76) | KDRKITFLT3PLK4MAP4K4 | |
| SCHEMBL4472667 | 0.79 | KIT (1.00) | KDRKITFLT3PLK4MAP4K4 | |
| SCHEMBL4473182 | 0.78 | KIT (0.76) | KDRKITFLT3PLK4MAP4K4 | |
| SCHEMBL4471506 | 0.74 | KDR (0.83) | KDRKITFLT3PLK4MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487841-B1 | THIOPYRIMIDINE AND ISOTHIAZOLOPYRIMIDINE KINASE INHIBITORS | ABBVIE INC (US) | 2014-01-15 | — | — | EP | disclosed |
| US-7560552-B2 | Thiopyrimidine and isothiazolopyrimidine kinase inhibitors | ABBOTT LABORATORIES (US) | 2009-07-14 | — | — | US | disclosed |
| US-20060276490-A1 | Thiopyrimidine and isothiazolopyrimidine Kinase Inhibitors | MICHAELIDES MICHAEL R | 2006-12-07 | — | — | US | disclosed |
| US-20040014756-A1 | Thiopyrimidine and isothiazolopyrimidine kinase inhibitors | ABBVIE INC. | 2004-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040014756-A1 | Thiopyrimidine and isothiazolopyrimidine kinase inhibitors | ABL1, ERBB2, LCK | KDR 425/4885KIT 394/4885FLT3 29/4885 |
| US-20060276490-A1 | Thiopyrimidine and isothiazolopyrimidine Kinase Inhibitors | ABL1, LCK, ERBB2 | KDR 391/4885KIT 361/4885FLT3 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.