Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 9/20 | 0.40 |
| ▸ | ATM | Q13315 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | DTYMK | P23919 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30728432 | 0.84 | NR1H2 (0.41) | NR1H2ATMKDM4ECYP1A2CYP3A4 | |
| SCHEMBL12685166 | 0.83 | POLB (0.41) | NR1H2ATMKDM4ECYP1A2CYP3A4 | |
| SCHEMBL30728434 | 0.83 | POLB (0.47) | NR1H2ATMKDM4ECYP1A2CYP3A4 | |
| SCHEMBL21147683 | 0.82 | POLB (0.41) | NR1H2ATMKDM4ECYP1A2CYP3A4 | |
| SCHEMBL28502078 | 0.82 | POLB (0.41) | NR1H2ATMKDM4ECYP1A2CYP3A4 | |
| SCHEMBL14873918 | 0.82 | POLB (0.41) | NR1H2ATMKDM4ECYP1A2CYP3A4 | |
| SCHEMBL18741314 | 0.80 | POLB (0.39) | NR1H2ATMKDM4ECYP1A2CYP3A4 | |
| SCHEMBL4008929 | 0.80 | POLB (0.39) | NR1H2ATMKDM4ECYP1A2CYP3A4 | |
| SCHEMBL4783033 | 0.79 | NR1H2 (0.53) | NR1H2NR1H3 | |
| SCHEMBL18181365 | 0.78 | CDK2 (0.47) | NR1H2KDM4EPOLBNR1H3GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1696920-A4 | COMPOUNDS AND METHODS FOR DEVELOPMENT OF RET MODULATORS | PLEXXIKON INC (US) | 2009-09-02 | — | — | EP | disclosed |
| EP-1696920-A2 | COMPOUNDS AND METHODS FOR DEVELOPMENT OF RET MODULATORS | PLEXXIKON, INC. (US) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005062795-A2 | COMPOUNDS AND METHODS FOR DEVELOPMENT OF RET MODULATORS | PLEXXIKON, INC. (US) | 2005-07-14 | — | — | WO | disclosed |