Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.64 |
| ▸ | FGFR4 | P22455 | 8/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.56 |
| ▸ | GSK3B | P49841 | 2/20 | 0.53 |
| ▸ | CDC7 | O00311 | 1/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.53 |
| ▸ | PIM1 | P11309 | 1/20 | 0.53 |
| ▸ | CDK2 | P24941 | 1/20 | 0.53 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.52 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.52 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4501960 | 0.89 | FGFR4 (0.61) | HDAC6FGFR4HDAC1HDAC2HDAC8 | |
| SCHEMBL4494633 | 0.89 | FGFR4 (0.60) | HDAC6FGFR4HDAC1HDAC2HDAC8 | |
| SCHEMBL4496537 | 0.88 | FGFR4 (0.58) | HDAC6FGFR4HDAC1HDAC2HDAC8 | |
| SCHEMBL4490455 | 0.88 | FGFR4 (0.62) | HDAC6FGFR4HDAC1HDAC2HDAC8 | |
| SCHEMBL4498565 | 0.87 | HDAC6 (0.59) | HDAC6FGFR4GSK3BCDC7MAP4K4 | |
| SCHEMBL4491476 | 0.87 | FGFR4 (0.60) | HDAC6FGFR4HDAC1HDAC2HDAC8 | |
| SCHEMBL4487154 | 0.86 | FGFR4 (0.58) | HDAC6FGFR4HDAC1HDAC2HDAC8 | |
| SCHEMBL4475421 | 0.86 | FGFR4 (0.68) | HDAC6FGFR4HDAC1HDAC2HDAC8 | |
| SCHEMBL4483693 | 0.86 | HDAC6 (0.59) | HDAC6FGFR4HDAC1HDAC2HDAC8 | |
| SCHEMBL4498316 | 0.85 | FGFR4 (0.56) | HDAC6FGFR4HDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |