Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 16/20 | 0.79 |
| ▸ | HCRTR2 | O43614 | 16/20 | 0.79 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | NTMT1 | Q9BV86 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4486880 | 0.88 | HCRTR1 (1.00) | HCRTR1HCRTR2MAPK1LMNATP53 | |
| SCHEMBL4477094 | 0.87 | HCRTR1 (0.81) | HCRTR1HCRTR2MAPK1LMNATP53 | |
| SCHEMBL4480261 | 0.87 | HCRTR1 (1.00) | HCRTR1HCRTR2MAPK1LMNATP53 | |
| SCHEMBL4481327 | 0.85 | HCRTR1 (0.79) | HCRTR1HCRTR2MAPK1LMNATP53 | |
| SCHEMBL4488195 | 0.85 | HCRTR1 (0.84) | HCRTR1HCRTR2MAPK1LMNATP53 | |
| SCHEMBL4498250 | 0.85 | HCRTR1 (0.78) | HCRTR1HCRTR2MAPK1LMNATP53 | |
| SCHEMBL4475398 | 0.85 | HCRTR1 (0.78) | HCRTR1HCRTR2MAPK1LMNATP53 | |
| SCHEMBL4482621 | 0.85 | HCRTR1 (0.86) | HCRTR1HCRTR2MAPK1LMNATP53 | |
| SCHEMBL4469637 | 0.85 | HCRTR1 (1.00) | HCRTR1HCRTR2LMNATP53CASP1 | |
| SCHEMBL8251630 | 0.83 | HCRTR1 (0.78) | HCRTR1HCRTR2MAPK1LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090118200-A1 | Proline bis-amide orexin receptor antagonists | MERCK SHARP & DOHME CORP. | 2009-05-07 | — | — | US | disclosed |
| US-20090118200-A1 | Proline bis-amide orexin receptor antagonists | MERCK SHARP & DOHME CORP. | 2009-05-07 | — | — | US | disclosed |
| US-20090118200-A1 | Proline bis-amide orexin receptor antagonists | MERCK SHARP & DOHME CORP. | 2009-05-07 | — | — | US | disclosed |
| WO-2006127550-A1 | PROLINE BIS-AMIDE OREXIN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2006-11-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118200-A1 | Proline bis-amide orexin receptor antagonists | HCRTR1, HCRTR2, NPSR1 | HCRTR1 1/4885HCRTR2 2/4885MAPK1 3740/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.