Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 7/20 | 0.81 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.81 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.81 |
| ▸ | GSK3B | P49841 | 12/20 | 0.76 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.69 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4485328 | 0.92 | HDAC1 (0.76) | HDAC1HDAC2HDAC8GSK3BCYP1A2 | |
| SCHEMBL4501685 | 0.90 | HDAC1 (0.76) | HDAC1HDAC2HDAC8GSK3BHDAC6 | |
| SCHEMBL1461499 | 0.90 | HDAC1 (0.78) | HDAC1HDAC2HDAC8GSK3BCYP1A2 | |
| SCHEMBL4495065 | 0.88 | GSK3B (0.83) | HDAC1HDAC2HDAC8GSK3BCYP1A2 | |
| SCHEMBL4498073 | 0.87 | HDAC1 (0.72) | HDAC1HDAC2HDAC8GSK3BHDAC6 | |
| SCHEMBL4494397 | 0.86 | HDAC6 (0.73) | HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL4492088 | 0.86 | HDAC1 (0.71) | HDAC1HDAC2HDAC8GSK3BHDAC6 | |
| SCHEMBL4492950 | 0.86 | HDAC1 (0.65) | HDAC1HDAC2HDAC8GSK3BCYP1A2 | |
| SCHEMBL4502352 | 0.86 | HDAC1 (0.70) | HDAC1HDAC2HDAC8GSK3BCYP1A2 | |
| SCHEMBL4493121 | 0.86 | GSK3B (1.00) | HDAC1HDAC2HDAC8GSK3BCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |