Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPT1A | P50416 | 15/20 | 0.35 |
| ▸ | CPT1B | Q92523 | 15/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CPT2 | P23786 | 2/20 | 0.33 |
| ▸ | RORC | P51449 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4487188 | 1.00 | CPT1A (0.35) | CPT1ACPT1BKDM4EMAPTCPT2 | |
| SCHEMBL227247 | 0.93 | CPT1A (0.33) | CPT1ACPT1BKDM4E | |
| SCHEMBL227248 | 0.93 | CPT1A (0.33) | CPT1ACPT1BKDM4E | |
| SCHEMBL4492258 | 0.92 | PLK1 (0.33) | CPT1ACPT1BKDM4ERORC | |
| SCHEMBL4492261 | 0.92 | PLK1 (0.33) | CPT1ACPT1BKDM4ERORC | |
| SCHEMBL4505088 | 0.91 | BACE1 (0.33) | KDM4EMAPTRORC | |
| SCHEMBL4505085 | 0.91 | BACE1 (0.33) | KDM4EMAPTRORC | |
| SCHEMBL4494978 | 0.91 | CPT1A (0.35) | CPT1ACPT1BKDM4EMAPTCPT2 | |
| SCHEMBL4494982 | 0.91 | CPT1A (0.35) | CPT1ACPT1BKDM4EMAPTCPT2 | |
| SCHEMBL4495336 | 0.91 | NPSR1 (0.33) | KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7514468-B2 | Indolinone derivatives substituted in the 6 position, the preparation thereof and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2009-04-07 | — | — | US | disclosed |
| US-20060194813-A1 | Indolinone derivatives substituted in the 6 position, the preparation thereof and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2006-08-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060194813-A1 | Indolinone derivatives substituted in the 6 position, the preparation thereof and their use as pharmaceutical compositions | KDR, FLT1, EGFR | CPT1A 1291/4885CPT1B 2676/4885KDM4E 1648/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.