Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 11/20 | 0.73 |
| ▸ | GSK3A | P49840 | 3/20 | 0.70 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.67 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.65 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.65 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.65 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.64 |
| ▸ | AAK1 | Q2M2I8 | 5/20 | 0.64 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.63 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.63 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.63 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.56 |
| ▸ | PIM1 | P11309 | 1/20 | 0.56 |
| ▸ | CDK2 | P24941 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4499397 | 0.89 | GSK3B (0.70) | GSK3BGSK3AHDAC6FGFR1FGFR2 | |
| SCHEMBL4491401 | 0.88 | GSK3B (0.73) | GSK3BGSK3AFGFR1FGFR2FGFR3 | |
| SCHEMBL4487680 | 0.85 | GSK3B (0.84) | GSK3BGSK3AHDAC6HDAC1HDAC2 | |
| SCHEMBL4494393 | 0.85 | GSK3B (0.68) | GSK3BGSK3AHDAC6FGFR1FGFR2 | |
| SCHEMBL4494131 | 0.85 | HDAC6 (0.71) | GSK3BHDAC6DYRK1AAAK1HDAC1 | |
| SCHEMBL4483349 | 0.85 | GSK3B (0.74) | GSK3BGSK3AHDAC6FGFR1FGFR2 | |
| SCHEMBL4500909 | 0.85 | HDAC6 (0.70) | GSK3BGSK3AHDAC6FGFR1FGFR2 | |
| SCHEMBL4499351 | 0.85 | DYRK1A (0.63) | GSK3BGSK3AHDAC6FGFR1FGFR2 | |
| SCHEMBL4494397 | 0.85 | HDAC6 (0.73) | HDAC6FGFR1FGFR2FGFR3DYRK1A | |
| SCHEMBL31060453 | 0.84 | GSK3B (1.00) | GSK3BGSK3AHDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |