Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 2/20 | 0.65 |
| ▸ | DHODH | Q02127 | 1/20 | 0.65 |
| ▸ | CASP3 | P42574 | 1/20 | 0.57 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.57 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.57 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | MAOB | P27338 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.51 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4488317 | 1.00 | PTPN1 (0.65) | PTPN1DHODHCASP3SENP8SENP7 | |
| SCHEMBL5516596 | 0.86 | MAOB (0.67) | PTPN1DHODHMEN1MAPTKMT2A | |
| SCHEMBL5516595 | 0.86 | MAOB (0.67) | PTPN1DHODHMEN1MAPTKMT2A | |
| SCHEMBL10713085 | 0.81 | CYP3A4 (0.58) | MEN1MAPTKMT2ALMNAMAOB | |
| SCHEMBL10713091 | 0.81 | CYP3A4 (0.58) | MEN1MAPTKMT2ALMNAMAOB | |
| SCHEMBL16424484 | 0.81 | PTPN1 (0.67) | PTPN1DHODHCASP3SENP8SENP7 | |
| Isobavachalcone SCHEMBL600137 | 0.79 | PTPN1 (1.00) | PTPN1DHODHCASP3SENP8SENP7 | |
| SCHEMBL14075645 | 0.77 | PDPK1 (0.69) | MEN1MAPTKMT2AMAOBNFKB1 | |
| SCHEMBL5519707 | 0.76 | PTPN1 (0.62) | PTPN1DHODHCASP3SENP8SENP7 | |
| SCHEMBL5519708 | 0.76 | PTPN1 (0.62) | PTPN1DHODHCASP3SENP8SENP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7498357-B2 | 1-[2,3-dihydro-4-hydroxy-2-(1-hydroxy-1,5-dimethyl-4-hexenyl)-benzofuran-5-yl]-3-(4-hydroxyphenyl)-2-propen-1-one; antiinflammatory, anticarcinogenic agent; nitrogen monoxide (NO) production suppresant, aldose reductase inhibitor; chronic rheumatic arthritis, osteoarthritis, gouty arthritis | TAKARA BIO INC. (JP) | 2009-03-03 | — | — | US | disclosed |
| US-7498357-B2 | 1-[2,3-dihydro-4-hydroxy-2-(1-hydroxy-1,5-dimethyl-4-hexenyl)-benzofuran-5-yl]-3-(4-hydroxyphenyl)-2-propen-1-one; antiinflammatory, anticarcinogenic agent; nitrogen monoxide (NO) production suppresant, aldose reductase inhibitor; chronic rheumatic arthritis, osteoarthritis, gouty arthritis | TAKARA BIO INC. (JP) | 2009-03-03 | — | — | US | disclosed |
| US-20070112066-A1 | Remedy | TAKARA BIO INC. (JP) | 2007-05-17 | — | — | US | disclosed |
| US-20070112066-A1 | Remedy | TAKARA BIO INC. (JP) | 2007-05-17 | — | — | US | disclosed |
| EP-1702912-A1 | REMEDY | TAKARA BIO INC. (JP) | 2006-09-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070112066-A1 | Remedy | AKR1B1, AKR1C2, ALDOA | PTPN1 1047/4885DHODH 353/4885CASP3 2852/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.