Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 5/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.43 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | CASP2 | P42575 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4480829 | 0.88 | GSK3B (0.48) | GSK3BHDAC6HDAC1HDAC2HDAC8 | |
| SCHEMBL4494521 | 0.88 | GSK3B (0.49) | GSK3BHDAC6HDAC1HDAC2HDAC8 | |
| SCHEMBL4477054 | 0.87 | HDAC6 (0.58) | GSK3BHDAC6HDAC1HDAC2HDAC8 | |
| SCHEMBL4486198 | 0.84 | AAK1 (0.52) | GSK3BHDAC6HDAC1HDAC2HDAC8 | |
| SCHEMBL4502796 | 0.84 | FGFR1 (0.52) | GSK3BHDAC6HDAC1HDAC2HDAC8 | |
| SCHEMBL4483860 | 0.83 | GSK3B (0.46) | GSK3BHDAC6HDAC1HDAC2HDAC8 | |
| SCHEMBL4493437 | 0.83 | HDAC6 (0.54) | GSK3BHDAC6HDAC1HDAC2HDAC8 | |
| SCHEMBL4503236 | 0.83 | GSK3B (0.50) | GSK3BHDAC6HDAC1HDAC2HDAC8 | |
| SCHEMBL4502553 | 0.83 | HDAC6 (0.55) | GSK3BHDAC6HDAC1HDAC2HDAC8 | |
| SCHEMBL4491583 | 0.83 | GSK3B (0.53) | GSK3BHDAC6HDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |