Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.64 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.64 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.64 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.51 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.51 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.51 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 3/20 | 0.50 |
| ▸ | ABL1 | P00519 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4503841 | 0.91 | HDAC6 (0.65) | HDAC6HDAC1HDAC2HDAC8FGFR1 | |
| SCHEMBL4491133 | 0.90 | HDAC6 (0.64) | HDAC6HDAC1HDAC2HDAC8FGFR1 | |
| SCHEMBL4490777 | 0.89 | HDAC1 (0.65) | HDAC6HDAC1HDAC2HDAC8FGFR1 | |
| SCHEMBL4489752 | 0.89 | HDAC1 (0.65) | HDAC6HDAC1HDAC2HDAC8FGFR1 | |
| SCHEMBL12886209 | 0.89 | HDAC6 (0.62) | HDAC6HDAC1HDAC2HDAC8FGFR1 | |
| SCHEMBL4482170 | 0.89 | HDAC6 (0.62) | HDAC6HDAC1HDAC2HDAC8ALDH1A1 | |
| SCHEMBL4500248 | 0.89 | HDAC1 (0.64) | HDAC6HDAC1HDAC2HDAC8FGFR1 | |
| SCHEMBL4494484 | 0.88 | HDAC6 (0.74) | HDAC6HDAC1HDAC2HDAC8HSD17B10 | |
| SCHEMBL4484791 | 0.87 | HDAC1 (0.62) | HDAC6HDAC1HDAC2HDAC8FGFR1 | |
| SCHEMBL12886236 | 0.87 | HDAC6 (0.60) | HDAC6HDAC1HDAC2HDAC8FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |