Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WEE2 | P0C1S8 | 2/20 | 0.71 |
| ▸ | WEE1 | P30291 | 2/20 | 0.71 |
| ▸ | PKMYT1 | Q99640 | 2/20 | 0.71 |
| ▸ | SRC | P12931 | 19/20 | 0.70 |
| ▸ | ABL1 | P00519 | 4/20 | 0.70 |
| ▸ | BCR | P11274 | 3/20 | 0.70 |
| ▸ | FYN | P06241 | 2/20 | 0.70 |
| ▸ | EGFR | P00533 | 2/20 | 0.70 |
| ▸ | SYK | P43405 | 2/20 | 0.70 |
| ▸ | STK25 | O00506 | 1/20 | 0.70 |
| ▸ | CIT | O14578 | 1/20 | 0.70 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.70 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.70 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.70 |
| ▸ | CASK | O14936 | 1/20 | 0.70 |
| ▸ | GAK | O14976 | 1/20 | 0.70 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.70 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.70 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.70 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5956094 | 0.93 | SRC (0.71) | WEE2WEE1PKMYT1SRCABL1 | |
| SCHEMBL6338535 | 0.92 | SRC (0.70) | WEE2WEE1PKMYT1SRCABL1 | |
| SCHEMBL4492083 | 0.90 | SRC (0.61) | WEE2WEE1PKMYT1SRCABL1 | |
| SCHEMBL4485027 | 0.90 | SRC (0.71) | SRCABL1BCRFYNEGFR | |
| SCHEMBL17375496 | 0.88 | SRC (0.69) | WEE2WEE1PKMYT1SRCABL1 | |
| SCHEMBL28416197 | 0.88 | SRC (0.69) | WEE2WEE1PKMYT1SRCABL1 | |
| SCHEMBL31167355 | 0.87 | SRC (0.71) | WEE2WEE1PKMYT1SRCABL1 | |
| SCHEMBL28457618 | 0.85 | SRC (0.66) | WEE2WEE1PKMYT1SRCABL1 | |
| SCHEMBL16706287 | 0.84 | WEE2 (1.00) | WEE2WEE1PKMYT1SRCABL1 | |
| SCHEMBL8213113 | 0.84 | SRC (0.70) | WEE2WEE1PKMYT1SRCABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110204490-B | Preparation method of disubstituted 4-chloroquinoline-3-carbonitrile derivative and bosutinib | 新发药业有限公司 | 2021-01-01 | — | — | CN | disclosed |
| CN-110204490-B | Preparation method of disubstituted 4-chloroquinoline-3-carbonitrile derivative and bosutinib | 新发药业有限公司 | 2021-01-01 | — | — | CN | disclosed |
| WO-2015198249-A1 | PROCESS FOR PREPARATION OF BOSUTINIB | SHILPA MEDICARE LIMITED (IN) | 2015-12-30 | — | — | WO | disclosed |
| WO-2015198249-A1 | PROCESS FOR PREPARATION OF BOSUTINIB | SHILPA MEDICARE LIMITED (IN) | 2015-12-30 | — | — | WO | disclosed |
| US-7501516-B2 | Quinoline derivatives and their use as tyrosine kinase inhibitors | ASTRAZENECA AB (SE) | 2009-03-10 | — | — | US | disclosed |
| US-20070213367-A1 | Substituted 3-cyanoquinolines as MEK inhibitors | ASTRAZENECA AB | 2007-09-13 | — | — | US | disclosed |
| US-20070191346-A1 | 3-Cyano-quinoline derivatives | ASTRAZENECA AB | 2007-08-16 | — | — | US | disclosed |
| US-7173136-B2 | 3-Cyano-quinoline derivatives | ASTRAZENECA AB (SE) | 2007-02-06 | — | — | US | disclosed |
| US-7173135-B2 | Substituted 3-cyanoquinolines as MEK inhibitors | ASTRAZENECA AB (SE) | 2007-02-06 | — | — | US | disclosed |
| EP-1409481-B1 | QUINOLINE DERIVATIVES AND THEIR USE AS TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2006-10-04 | — | — | EP | disclosed |
| WO-2004041811-A1 | 3-CYANO-QUINOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2004-05-21 | — | — | WO | disclosed |
| EP-1409481-A1 | QUINOLINE DERIVATIVES AND THEIR USE AS TYROSINE KINASE INHIBITORS | Astrazeneca AB (SE) | 2004-04-21 | — | — | EP | disclosed |
| WO-2004005284-A1 | SUBSTITUTED 3-CYANOQUINOLINES AS MEK INHIBITORS | ASTRAZENECA AB (SE) | 2004-01-15 | — | — | WO | disclosed |
| WO-2003053960-A2 | QUINLINE DERIVATES AND THEIR USE AS MEK INHIBITORS | ASTRAZENECA AB (SE) | 2003-07-03 | — | — | WO | disclosed |
| WO-2003047585-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING BENZOFURANYL SUBSTITUTED 3-CYANOQUINOLINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF SOLID TUMOURS | ASTRAZENECA AB (SE) | 2003-06-12 | — | — | WO | disclosed |
| WO-2003047584-A1 | QUINOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2003-06-12 | — | — | WO | disclosed |
| WO-2003047583-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING BENZOFURANYL SUBSTITUTED 3-CYANOQUINOLINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF SOLID TUMOURS | ASTRAZENECA AB (SE) | 2003-06-12 | — | — | WO | disclosed |
| WO-2003047582-A1 | QUINOLINE DERIVATIVES AS ANTITUMOUR AGENTS | ASTRAZENECA AB (SE) | 2003-06-12 | — | — | WO | disclosed |
| WO-2003048159-A1 | QUINOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2003-06-12 | — | — | WO | disclosed |
| WO-2003008409-A1 | QUINOLINE DERIVATIVES AND THEIR USE AS TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2003-01-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070213367-A1 | Substituted 3-cyanoquinolines as MEK inhibitors | NRAS, BRAF, MAPK1 | WEE2 167/4885WEE1 142/4885PKMYT1 612/4885 |
| US-20070191346-A1 | 3-Cyano-quinoline derivatives | MKI67, CCNA1, CCNT1 | WEE2 1872/4885WEE1 1241/4885PKMYT1 2871/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.