Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 13/20 | 0.61 |
| ▸ | GSK3A | P49840 | 1/20 | 0.59 |
| ▸ | GSK3B | P49841 | 1/20 | 0.59 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.54 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.54 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.54 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.53 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.52 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4503216 | 0.89 | HDAC6 (0.61) | HDAC6FGFR1FGFR2FGFR3FGFR4 | |
| SCHEMBL4559843 | 0.88 | HDAC6 (0.68) | HDAC6FGFR1FGFR2FGFR3FGFR4 | |
| SCHEMBL4484176 | 0.88 | HDAC6 (0.60) | HDAC6FGFR1FGFR2FGFR3FGFR4 | |
| SCHEMBL4494426 | 0.88 | HDAC6 (0.61) | HDAC6FGFR1FGFR2FGFR3ABCB1 | |
| SCHEMBL4497680 | 0.87 | HDAC6 (0.79) | HDAC6GSK3BFGFR1FGFR2FGFR3 | |
| SCHEMBL4497900 | 0.87 | HDAC6 (0.67) | HDAC6GSK3BFGFR1FGFR2FGFR3 | |
| SCHEMBL4489139 | 0.87 | HDAC6 (0.69) | HDAC6GSK3BFGFR1FGFR2FGFR3 | |
| SCHEMBL4504067 | 0.87 | AAK1 (0.62) | HDAC6FGFR1FGFR2FGFR3FGFR4 | |
| SCHEMBL4491909 | 0.86 | HDAC6 (0.73) | HDAC6GSK3BFGFR1FGFR2FGFR3 | |
| SCHEMBL4495749 | 0.86 | HDAC6 (0.57) | HDAC6GSK3BFGFR1FGFR2FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |