Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 6/20 | 0.63 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.63 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.63 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.60 |
| ▸ | GSK3B | P49841 | 11/20 | 0.56 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4559844 | 0.94 | HDAC6 (0.62) | HDAC1HDAC2HDAC8HDAC6GSK3B | |
| SCHEMBL4502964 | 0.92 | HDAC1 (0.63) | HDAC1HDAC2HDAC8HDAC6GSK3B | |
| SCHEMBL4480272 | 0.91 | HDAC1 (0.66) | HDAC1HDAC2HDAC8HDAC6GSK3B | |
| SCHEMBL4491927 | 0.91 | HDAC6 (0.62) | HDAC1HDAC2HDAC8HDAC6GSK3B | |
| SCHEMBL4489922 | 0.91 | HDAC1 (0.62) | HDAC1HDAC2HDAC8HDAC6GSK3B | |
| SCHEMBL4491092 | 0.88 | HDAC6 (0.61) | HDAC1HDAC2HDAC8HDAC6GSK3B | |
| SCHEMBL4503672 | 0.88 | HDAC6 (0.61) | HDAC1HDAC2HDAC8HDAC6GSK3B | |
| SCHEMBL4480331 | 0.88 | GSK3B (0.61) | GSK3B | |
| SCHEMBL4479022 | 0.87 | GSK3B (0.71) | GSK3B | |
| SCHEMBL4498125 | 0.87 | HDAC1 (0.58) | HDAC1HDAC2HDAC8HDAC6GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |