Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 18/20 | 0.71 |
| ▸ | GAK | O14976 | 7/20 | 0.52 |
| ▸ | STK16 | O75716 | 7/20 | 0.52 |
| ▸ | BMP2K | Q9NSY1 | 7/20 | 0.52 |
| ▸ | GSK3A | P49840 | 2/20 | 0.51 |
| ▸ | GSK3B | P49841 | 2/20 | 0.51 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.50 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.50 |
| ▸ | CDKL2 | Q92772 | 1/20 | 0.50 |
| ▸ | RIOK1 | Q9BRS2 | 1/20 | 0.50 |
| ▸ | MYLK2 | Q9H1R3 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4503971 | 0.93 | AAK1 (0.71) | AAK1GAKSTK16BMP2KGSK3A | |
| SCHEMBL4505247 | 0.89 | AAK1 (0.68) | AAK1GAKSTK16BMP2KGSK3A | |
| SCHEMBL4491206 | 0.87 | AAK1 (0.54) | AAK1GAKSTK16BMP2KGSK3A | |
| SCHEMBL4502391 | 0.85 | HDAC1 (0.66) | AAK1GSK3AGSK3B | |
| SCHEMBL4491947 | 0.84 | GSK3B (0.56) | AAK1GSK3AGSK3B | |
| SCHEMBL12886198 | 0.83 | HDAC6 (0.57) | AAK1GSK3AGSK3B | |
| SCHEMBL12886041 | 0.83 | AAK1 (0.52) | AAK1GAKSTK16BMP2KGSK3A | |
| SCHEMBL4484349 | 0.82 | HDAC6 (0.58) | AAK1GSK3AGSK3B | |
| SCHEMBL4492106 | 0.80 | GSK3B (0.53) | AAK1GAKSTK16BMP2KGSK3A | |
| SCHEMBL4492221 | 0.80 | GSK3B (0.69) | AAK1GSK3AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |