Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 7/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.57 |
| ▸ | GSK3B | P49841 | 2/20 | 0.56 |
| ▸ | CDK2 | P24941 | 1/20 | 0.56 |
| ▸ | GSK3A | P49840 | 1/20 | 0.56 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.52 |
| ▸ | PRKACA | P17612 | 5/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4498073 | 0.88 | HDAC1 (0.72) | HDAC1HDAC2HDAC8GSK3BHDAC6 | |
| SCHEMBL4496581 | 0.87 | HDAC1 (0.65) | HDAC1HDAC2HDAC8GSK3BHDAC6 | |
| SCHEMBL4488439 | 0.85 | GSK3B (0.65) | HDAC1HDAC2HDAC8GSK3BCDK2 | |
| SCHEMBL4494216 | 0.84 | HDAC1 (0.59) | HDAC1HDAC2HDAC8GSK3BCDK2 | |
| SCHEMBL4559902 | 0.84 | GSK3B (0.63) | HDAC1HDAC2HDAC8GSK3BHDAC6 | |
| SCHEMBL4479937 | 0.84 | HDAC1 (0.62) | HDAC1HDAC2HDAC8GSK3BPRKACA | |
| SCHEMBL4491247 | 0.84 | HDAC1 (0.65) | HDAC1HDAC2HDAC8GSK3BCDK2 | |
| SCHEMBL4500115 | 0.83 | GSK3B (0.66) | HDAC1HDAC2HDAC8GSK3BCDK2 | |
| SCHEMBL4492088 | 0.83 | HDAC1 (0.71) | HDAC1HDAC2HDAC8GSK3BHDAC6 | |
| SCHEMBL4557773 | 0.83 | GSK3B (0.64) | HDAC1HDAC2HDAC8GSK3BHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |