Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 8/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.49 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4476112 | 0.92 | HDAC1 (0.56) | HDAC1HDAC2HDAC8HDAC6GSK3B | |
| SCHEMBL4498522 | 0.89 | HDAC1 (0.55) | HDAC1HDAC2HDAC8HDAC6AAK1 | |
| SCHEMBL4499787 | 0.88 | HDAC6 (0.64) | HDAC1HDAC2HDAC8HDAC6AAK1 | |
| SCHEMBL4486782 | 0.87 | HDAC1 (0.68) | HDAC1HDAC2HDAC8MAPK1HDAC6 | |
| SCHEMBL4502400 | 0.87 | HDAC1 (0.54) | HDAC1HDAC2HDAC8HDAC6AAK1 | |
| SCHEMBL4488079 | 0.86 | HDAC1 (0.56) | HDAC1HDAC2HDAC8MAPK1HDAC6 | |
| SCHEMBL4488634 | 0.85 | HDAC1 (0.54) | HDAC1HDAC2HDAC8HDAC6AAK1 | |
| SCHEMBL4495192 | 0.85 | GSK3B (0.59) | HDAC1HDAC2HDAC8AAK1GSK3B | |
| SCHEMBL4494626 | 0.84 | HDAC1 (0.54) | HDAC1HDAC2HDAC8HDAC6GSK3B | |
| SCHEMBL4494068 | 0.84 | HDAC1 (0.54) | HDAC1HDAC2HDAC8HDAC6AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |