Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 9/20 | 0.57 |
| ▸ | CDK2 | P24941 | 4/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.48 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4485485 | 0.90 | GSK3B (0.60) | GSK3BHDAC1HDAC2HDAC8 | |
| SCHEMBL4502174 | 0.88 | GSK3B (0.56) | GSK3BHDAC1HDAC2HDAC8AURKB | |
| SCHEMBL4483435 | 0.88 | GSK3B (0.72) | GSK3BCDK2HDAC1HDAC2HDAC8 | |
| SCHEMBL4480712 | 0.88 | HDAC1 (0.56) | GSK3BCDK2HDAC1HDAC2HDAC8 | |
| SCHEMBL4482695 | 0.87 | GSK3B (0.64) | GSK3BCDK2HDAC1HDAC2HDAC8 | |
| SCHEMBL4506246 | 0.85 | GSK3B (0.67) | GSK3B | |
| SCHEMBL4484894 | 0.84 | GSK3B (0.53) | GSK3BCDK2AURKB | |
| SCHEMBL4480196 | 0.84 | FGFR1 (0.65) | GSK3B | |
| SCHEMBL4497978 | 0.84 | GSK3B (0.57) | GSK3BHDAC1HDAC2HDAC8 | |
| SCHEMBL4480790 | 0.82 | DYRK1A (0.57) | GSK3BCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |