Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 13/20 | 0.64 |
| ▸ | GSK3B | P49841 | 5/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | GSK3A | P49840 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4498066 | 0.94 | HDAC6 (0.58) | HDAC6GSK3BFGFR1FGFR2FGFR3 | |
| SCHEMBL4503174 | 0.88 | HDAC6 (0.55) | HDAC6GSK3BFGFR1FGFR2FGFR3 | |
| SCHEMBL4496084 | 0.88 | GSK3B (0.60) | HDAC6GSK3BFGFR1FGFR2FGFR3 | |
| SCHEMBL4488442 | 0.88 | HDAC6 (0.65) | HDAC6GSK3BFGFR1FGFR2FGFR3 | |
| SCHEMBL4502157 | 0.88 | HDAC6 (0.51) | HDAC6GSK3BFGFR1FGFR2FGFR3 | |
| SCHEMBL4500881 | 0.87 | HDAC6 (0.62) | HDAC6GSK3BFGFR1FGFR2FGFR3 | |
| SCHEMBL4494493 | 0.86 | GSK3B (0.57) | HDAC6GSK3BFGFR1FGFR2FGFR3 | |
| SCHEMBL4475921 | 0.85 | HDAC6 (0.53) | HDAC6GSK3BFGFR1FGFR2FGFR3 | |
| SCHEMBL4504366 | 0.83 | GSK3B (0.59) | HDAC6GSK3BFGFR1FGFR2FGFR3 | |
| SCHEMBL4501584 | 0.83 | FGFR4 (0.54) | HDAC6GSK3BFGFR1FGFR2FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |