Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 8/20 | 0.72 |
| ▸ | GSK3A | P49840 | 8/20 | 0.69 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.63 |
| ▸ | AAK1 | Q2M2I8 | 9/20 | 0.62 |
| ▸ | CDK2 | P24941 | 5/20 | 0.62 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.62 |
| ▸ | PIM1 | P11309 | 1/20 | 0.62 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.60 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.60 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.60 |
| ▸ | GAK | O14976 | 1/20 | 0.58 |
| ▸ | STK16 | O75716 | 1/20 | 0.58 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4502945 | 0.98 | GSK3B (0.72) | GSK3BGSK3AHDAC6AAK1CDK2 | |
| SCHEMBL4495239 | 0.96 | GSK3B (0.78) | GSK3BGSK3AHDAC6AAK1CDK2 | |
| SCHEMBL4565017 | 0.88 | GSK3B (0.92) | GSK3BGSK3AAAK1CDK2PIK3CD | |
| SCHEMBL4497986 | 0.87 | GSK3B (0.69) | GSK3BGSK3AAAK1CDK2PIK3CD | |
| SCHEMBL4481694 | 0.87 | GSK3A (0.91) | GSK3BGSK3AAAK1CDK2PIK3CD | |
| SCHEMBL4497022 | 0.86 | GSK3B (0.77) | GSK3BGSK3AAAK1CDK2PIK3CD | |
| SCHEMBL4479758 | 0.86 | GSK3B (0.92) | GSK3BGSK3AAAK1CDK2PIK3CD | |
| SCHEMBL4476544 | 0.85 | GSK3B (0.73) | GSK3BGSK3AAAK1CDK2PIK3CD | |
| SCHEMBL4490055 | 0.85 | GSK3A (0.88) | GSK3BGSK3AAAK1CDK2PIK3CD | |
| SCHEMBL4492327 | 0.85 | HDAC6 (0.66) | GSK3BGSK3AHDAC6AAK1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |