Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.45 |
| ▸ | ACHE | P22303 | 8/20 | 0.43 |
| ▸ | BCHE | P06276 | 6/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4493665 | 1.00 | TMEM97 (0.45) | TMEM97SIGMAR1ACHEBCHENAMPT | |
| SCHEMBL4501074 | 0.94 | TMEM97 (0.46) | TMEM97SIGMAR1ACHEBCHE | |
| SCHEMBL4501080 | 0.94 | TMEM97 (0.46) | TMEM97SIGMAR1ACHEBCHE | |
| SCHEMBL4487046 | 0.93 | LSS (0.44) | TMEM97SIGMAR1KDM4E | |
| SCHEMBL4487048 | 0.93 | LSS (0.44) | TMEM97SIGMAR1KDM4E | |
| SCHEMBL4487655 | 0.93 | TMEM97 (0.45) | TMEM97SIGMAR1ACHEBCHE | |
| SCHEMBL4491461 | 0.93 | TMEM97 (0.45) | TMEM97SIGMAR1ACHEBCHE | |
| SCHEMBL4494974 | 0.93 | TMEM97 (0.45) | TMEM97SIGMAR1ACHEBCHERORC | |
| SCHEMBL4491462 | 0.93 | TMEM97 (0.45) | TMEM97SIGMAR1ACHEBCHE | |
| SCHEMBL4494969 | 0.93 | TMEM97 (0.45) | TMEM97SIGMAR1ACHEBCHERORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7514468-B2 | Indolinone derivatives substituted in the 6 position, the preparation thereof and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2009-04-07 | — | — | US | disclosed |
| US-20060194813-A1 | Indolinone derivatives substituted in the 6 position, the preparation thereof and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2006-08-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060194813-A1 | Indolinone derivatives substituted in the 6 position, the preparation thereof and their use as pharmaceutical compositions | KDR, FLT1, EGFR | TMEM97 2293/4885SIGMAR1 916/4885ACHE 2967/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.