Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.54 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.54 |
| ▸ | MMP3 | P08254 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 2/20 | 0.31 |
| ▸ | MMP9 | P14780 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2469915 | 0.76 | HSP90AA1 (0.58) | HSP90AA1HSP90AB1MMP3KDM4EALDH1A1 | |
| SCHEMBL464711 | 0.75 | HSP90AA1 (0.70) | HSP90AA1HSP90AB1MMP3KDM4EALDH1A1 | |
| SCHEMBL446516 | 0.74 | HSP90AA1 (0.42) | HSP90AA1HSP90AB1KDM4EOPRM1OPRL1 | |
| SCHEMBL464655 | 0.74 | HSP90AA1 (0.68) | HSP90AA1HSP90AB1MMP3KDM4EALDH1A1 | |
| Elesclomol SCHEMBL313745 | 0.72 | HSP90AA1 (1.00) | HSP90AA1HSP90AB1KDM4EALDH1A1MAPT | |
| SCHEMBL445766 | 0.72 | HSP90AA1 (0.58) | HSP90AA1HSP90AB1ALDH1A1MAPTKMT2A | |
| Elesclomol SCHEMBL2819576 | 0.71 | HSP90AA1 (0.97) | HSP90AA1HSP90AB1KDM4EALDH1A1MAPT | |
| SCHEMBL12808820 | 0.71 | HSP90AA1 (0.84) | HSP90AA1HSP90AB1KDM4EALDH1A1MAPT | |
| SCHEMBL446362 | 0.71 | HSP90AA1 (0.63) | HSP90AA1HSP90AB1ALDH1A1MAPTKMT2A | |
| SCHEMBL446533 | 0.70 | HSP90AA1 (0.62) | HSP90AA1HSP90AB1ALDH1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8680100-B2 | Sulfonylhydrazide compounds for treating proliferative disorders | SYNTA PHARMACEUTICALS CORP. (US) | 2014-03-25 | — | — | US | disclosed |
| US-20120065206-A1 | COMPOUNDS FOR TREATING PROLIFERATIVE DISORDERS | SYNTA PHARMACEUTICALS CORP. (US) | 2012-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065206-A1 | COMPOUNDS FOR TREATING PROLIFERATIVE DISORDERS | PKD1, PKD2, PCNA | HSP90AA1 2300/4885HSP90AB1 1711/4885MMP3 1856/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.