Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 7/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.42 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4493015 | 0.89 | MEN1 (0.57) | HDAC1HDAC2HDAC8HDAC6MEN1 | |
| SCHEMBL4482298 | 0.88 | HDAC6 (0.62) | HDAC1HDAC2HDAC8HDAC6MEN1 | |
| SCHEMBL4488079 | 0.85 | HDAC1 (0.56) | HDAC1HDAC2HDAC8HDAC6MAPK1 | |
| SCHEMBL4488476 | 0.83 | HDAC1 (0.53) | HDAC1HDAC2HDAC8HDAC6MAPT | |
| SCHEMBL4494626 | 0.83 | HDAC1 (0.54) | HDAC1HDAC2HDAC8HDAC6GSK3B | |
| SCHEMBL4491831 | 0.82 | HDAC1 (0.62) | HDAC1HDAC2HDAC8GSK3BCYP1A2 | |
| SCHEMBL4494443 | 0.81 | HDAC1 (0.59) | HDAC1HDAC2HDAC8HDAC6GSK3B | |
| SCHEMBL4499137 | 0.81 | HDAC6 (0.55) | HDAC1HDAC2HDAC8HDAC6GSK3B | |
| SCHEMBL4493069 | 0.80 | HDAC6 (0.67) | HDAC1HDAC2HDAC8HDAC6FGFR1 | |
| SCHEMBL4484894 | 0.80 | GSK3B (0.53) | MEN1KMT2APOLBMAPTGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |