SCHEMBL449433

SCHEMBL449433

Clc1ccn[c]n1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL450929 0.67
SCHEMBL144535 0.67
SCHEMBL17263863 0.67
SCHEMBL557782 0.65 IDO1 (0.43)
SCHEMBL6965549 0.62
SCHEMBL4269086 0.62
SCHEMBL16793432 0.62
SCHEMBL445862 0.62
SCHEMBL533497 0.62
SCHEMBL655266 0.62

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 549 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240034737-A1 Heterocyclic Derivatives as P2X7 Receptor Antagonists BREYE THERAPEUTICS APS (DK) 2024-02-01 US claimed
US-20230416260-A1 Inhibitors of the MYST Family of Lysine Acetyl Transferases Isosterix, Inc. 2023-12-28 US claimed
CN-117157291-A Heterocyclic derivatives as P2X7 receptor antagonists 布雷耶疗法有限公司 2023-12-01 CN claimed
US-20230357218-A1 N-FORMAMIDOPYRAZOLINE DERIVATIVE AS P2X3 RECEPTOR ANTAGONIST AND USE THEREOF HANGZHOU WESTAN PHARMACEUTICAL TECHNOLOGY CO., LTD (CN) 2023-11-09 US claimed
EP-4262975-A1 HETEROCYCLIC DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS Breye Therapeutics ApS (DK) 2023-10-25 EP claimed
WO-2023192817-A1 INHIBITORS OF THE MYST FAMILY OF LYSINE ACETYL TRANSFERASES Isosterix, Inc. (US) 2023-10-05 WO claimed
US-20230303580-A1 INHIBITORS OF THE MYST FAMILY OF LYSINE ACETYL TRANSFERASES Isosterix, Inc. 2023-09-28 US claimed
US-20230132715-A1 IRAK DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2023-05-04 US claimed
CN-113214240-B N-formamido pyrazoline derivative as P2X3 receptor antagonist and application thereof 杭州维坦医药科技有限公司 2022-12-06 CN claimed
EP-4079725-A1 N-CARBOXAMIDOPYRAZOLINE DERIVATIVE SERVING AS P2X3 RECEPTOR ANTAGONIST AND APPLICATIONS Hangzhou Westan Pharmaceutical Technology Co., Ltd. (CN) 2022-10-26 EP claimed
EP-0625520-A2 Thiazolotriazole and thiazolodiazole derivatives with fungicidal activity ISAGRO S.r.l. (IT) 1994-11-23 EP claimed
WO-1994020491-A1 BENZOPYRANES AS POTASSIUM CHANNEL OPENERS PFIZER LIMITED (GB) 1994-09-15 WO claimed
EP-0154442-B1 A COLOUR MEMBER AND METHOD OF MANUFACTURING THE SAME SEIKO INSTRUMENTS INC. (JP) 1992-09-09 EP claimed
US-4847139-A PRETREATMENT OF POLYMERIC BASE WITH NOBLE METAL ACTIVATORS, DECLADDING METAL FOIL, ELECTROLESS METALLIZATION BAYER AKTIENGESELLSCHAFT (DE) 1989-07-11 US claimed
US-4781444-A Color member having electrodeposited color layer composed of polymer and coloring matter bonded to polymer and method for manufacturing same SEIKO INSTRUMENTS & ELECTRONICS LTD. (JP) 1988-11-01 US claimed
EP-0273300-A2 Process for the one-bath single-stage dyeing of mixtures of carrier-free dyeable polyester fibres and cellulose fibres HOECHST AKTIENGESELLSCHAFT (DE) 1988-07-06 EP claimed
EP-0130711-B1 AQUEOUS SOLUTIONS OF REACTIVE DYES ICI AMERICAS INC. (US) 1987-02-11 EP claimed
EP-0154442-A2 A colour member and method of manufacturing the same SEIKO INSTRUMENTS INC. (JP) 1985-09-11 EP claimed
US-4471079-A POLYMERIC DYE FROM POLYMER CONTAINING AMINO GROUPS AND ANIONIC OR REACTIVE DYE PILOT MAN-NEN HITSU KABUSHIKI KAISHA (JP) 1984-09-11 US claimed
US-4338093-A Process for dyeing with reactive dyestuffs BAYER AKTIENGESELLSCHAFT (DE) 1982-07-06 US claimed