Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.69 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.69 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.69 |
| ▸ | GSK3B | P49841 | 10/20 | 0.62 |
| ▸ | GSK3A | P49840 | 9/20 | 0.62 |
| ▸ | AAK1 | Q2M2I8 | 8/20 | 0.62 |
| ▸ | CDK2 | P24941 | 5/20 | 0.62 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.62 |
| ▸ | PIM1 | P11309 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4492977 | 0.96 | HDAC1 (0.65) | HDAC1HDAC2HDAC8GSK3BGSK3A | |
| SCHEMBL4494476 | 0.96 | HDAC1 (0.65) | HDAC1HDAC2HDAC8GSK3BGSK3A | |
| SCHEMBL4504402 | 0.93 | HDAC1 (0.71) | HDAC1HDAC2HDAC8GSK3BGSK3A | |
| SCHEMBL4493477 | 0.89 | HDAC1 (0.66) | HDAC1HDAC2HDAC8GSK3BGSK3A | |
| SCHEMBL4491018 | 0.89 | GSK3B (0.76) | HDAC1HDAC2HDAC8GSK3BGSK3A | |
| SCHEMBL4497447 | 0.89 | HDAC1 (0.66) | HDAC1HDAC2HDAC8GSK3BGSK3A | |
| SCHEMBL4493050 | 0.89 | GSK3B (0.72) | HDAC1HDAC2HDAC8GSK3BGSK3A | |
| SCHEMBL4495293 | 0.88 | HDAC1 (0.76) | HDAC1HDAC2HDAC8GSK3BGSK3A | |
| SCHEMBL4493711 | 0.88 | HDAC1 (0.65) | HDAC1HDAC2HDAC8GSK3BGSK3A | |
| SCHEMBL4495192 | 0.87 | GSK3B (0.59) | HDAC1HDAC2HDAC8GSK3BGSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |