Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 11/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | SCN1A | P35498 | 1/20 | 0.49 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.49 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HTR3A | P46098 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4505134 | 0.85 | HRH3 (0.61) | HRH3MAOBSLC6A2SLC6A4 | |
| SCHEMBL4506398 | 0.84 | HRH3 (0.65) | HRH3MAOBSLC6A2GLAL3MBTL1 | |
| SCHEMBL4499048 | 0.83 | HRH3 (0.64) | HRH3SLC6A2SLC6A4GLAL3MBTL1 | |
| SCHEMBL4509190 | 0.83 | HRH3 (0.64) | HRH3MAOBSLC6A2SLC6A4GLA | |
| SCHEMBL4501875 | 0.82 | HRH3 (0.63) | HRH3MAOB | |
| SCHEMBL4499089 | 0.82 | HRH3 (0.65) | HRH3MAOB | |
| SCHEMBL4514549 | 0.82 | HRH3 (0.65) | HRH3MAOB | |
| SCHEMBL4490295 | 0.82 | HRH3 (0.65) | HRH3MAOB | |
| SCHEMBL4505460 | 0.82 | HRH3 (0.68) | HRH3MAOBSLC6A2 | |
| SCHEMBL4490636 | 0.81 | HRH3 (0.64) | HRH3MAOBSLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7608617-B2 | Naphthaline derivatives as H3 inverse agonists | HOFFMANN-LA ROCHE INC. (US) | 2009-10-27 | — | — | US | disclosed |