Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 9/20 | 0.67 |
| ▸ | GSK3A | P49840 | 9/20 | 0.67 |
| ▸ | GSK3B | P49841 | 9/20 | 0.67 |
| ▸ | CDK2 | P24941 | 5/20 | 0.67 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.67 |
| ▸ | PIM1 | P11309 | 1/20 | 0.67 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4487011 | 0.98 | AAK1 (0.67) | AAK1GSK3AGSK3BCDK2PIK3CD | |
| SCHEMBL4502153 | 0.95 | AAK1 (0.74) | AAK1GSK3AGSK3BCDK2PIK3CD | |
| SCHEMBL4488315 | 0.92 | GSK3B (0.72) | AAK1GSK3AGSK3BCDK2PIK3CD | |
| SCHEMBL4488385 | 0.91 | GSK3A (0.71) | AAK1GSK3AGSK3BCDK2PIK3CD | |
| SCHEMBL4492207 | 0.91 | GSK3B (0.71) | AAK1GSK3AGSK3BCDK2PIK3CD | |
| SCHEMBL4494840 | 0.90 | GSK3A (0.70) | AAK1GSK3AGSK3BCDK2PIK3CD | |
| SCHEMBL4485822 | 0.89 | AAK1 (0.72) | AAK1GSK3AGSK3BCDK2PIK3CD | |
| SCHEMBL4484280 | 0.87 | AAK1 (0.80) | AAK1GSK3AGSK3BCDK2PIK3CD | |
| SCHEMBL4483748 | 0.86 | GSK3A (0.78) | AAK1GSK3AGSK3BCDK2PIK3CD | |
| SCHEMBL4487781 | 0.86 | AAK1 (0.61) | AAK1GSK3AGSK3BCDK2PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |