Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.47 |
| ▸ | SLC6A9 | P48067 | 12/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.34 |
| ▸ | NQO2 | P16083 | 1/20 | 0.34 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.34 |
| ▸ | ACTR2 | P61160 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4496178 | 1.00 | MAPK14 (0.47) | MAPK14SLC6A9MAPK11MAPK13MAPK12 | |
| SCHEMBL4512122 | 0.91 | MAPK14 (0.49) | MAPK14SLC6A9MAPK11MAPK13MAPK12 | |
| SCHEMBL4512123 | 0.91 | MAPK14 (0.49) | MAPK14SLC6A9MAPK11MAPK13MAPK12 | |
| SCHEMBL4496507 | 0.89 | MAPK14 (0.60) | MAPK14MAPK11MAPK13MAPK12NQO2 | |
| SCHEMBL4502035 | 0.85 | MAPK14 (0.64) | MAPK14SLC6A9MAPK11MAPK13MAPK12 | |
| SCHEMBL4502033 | 0.85 | MAPK14 (0.64) | MAPK14SLC6A9MAPK11MAPK13MAPK12 | |
| SCHEMBL4495662 | 0.84 | CYP2C19 (0.44) | MAPK14SLC6A9 | |
| SCHEMBL4495663 | 0.84 | CYP2C19 (0.44) | MAPK14SLC6A9 | |
| SCHEMBL4493197 | 0.80 | MAPK14 (0.52) | MAPK14SLC6A9MAPK11MAPK13MAPK12 | |
| SCHEMBL4493201 | 0.80 | MAPK14 (0.52) | MAPK14SLC6A9MAPK11MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7488744-B2 | Indole-type derivatives as inhibitors of p38 kinase | SCIOS, INC. (US) | 2009-02-10 | — | — | US | disclosed |
| US-20070232617-A1 | INDOLE-TYPE DERIVATIVES AS INHIBITORS OF P38 KINASE | SCIOS, INC. (US) | 2007-10-04 | — | — | US | disclosed |
| US-7220763-B2 | Indole-type derivatives as inhibitors of p38 kinase | SCIOS, INC. (US) | 2007-05-22 | — | — | US | disclosed |
| US-20040142940-A1 | Indole-type derivatives as inhibitors of p38 kinase | SCIOS, INC. | 2004-07-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040142940-A1 | Indole-type derivatives as inhibitors of p38 kinase | MAPK1, MAPKAPK2, MAPK4 | MAPK14 28/4885SLC6A9 3137/4885MAPK11 48/4885 |
| US-20070232617-A1 | INDOLE-TYPE DERIVATIVES AS INHIBITORS OF P38 KINASE | MAPK1, MAPKAPK2, MAPKAPK5 | MAPK14 38/4885SLC6A9 3515/4885MAPK11 52/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.