Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDKN1A | P38936 | 1/20 | 0.79 |
| ▸ | GSK3A | P49840 | 2/20 | 0.52 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.52 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.52 |
| ▸ | PIM1 | P11309 | 2/20 | 0.52 |
| ▸ | BRAF | P15056 | 11/20 | 0.51 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.50 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.48 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.48 |
| ▸ | AKT1 | P31749 | 1/20 | 0.48 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.48 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5799706 | 0.93 | CDKN1A (0.76) | CDKN1AGSK3AEPHA2MAPK13PIM1 | |
| SCHEMBL5813193 | 0.93 | CDKN1A (0.76) | CDKN1AGSK3AEPHA2MAPK13PIM1 | |
| SCHEMBL5808894 | 0.92 | CDKN1A (0.79) | CDKN1AGSK3AEPHA2MAPK13PIM1 | |
| SCHEMBL5613426 | 0.91 | CDKN1A (0.77) | CDKN1AGSK3AEPHA2MAPK13PIM1 | |
| SCHEMBL5811516 | 0.91 | CDKN1A (0.77) | CDKN1AGSK3AEPHA2MAPK13PIM1 | |
| SCHEMBL5797539 | 0.91 | CDKN1A (0.72) | CDKN1AGSK3AEPHA2MAPK13PIM1 | |
| SCHEMBL5807557 | 0.91 | CDKN1A (0.74) | CDKN1AGSK3AEPHA2MAPK13PIM1 | |
| SCHEMBL5812738 | 0.91 | CDKN1A (0.74) | CDKN1AGSK3AEPHA2MAPK13PIM1 | |
| SCHEMBL5946650 | 0.90 | CDKN1A (0.75) | CDKN1AGSK3AEPHA2MAPK13PIM1 | |
| SCHEMBL5819966 | 0.90 | CDKN1A (0.75) | CDKN1AGSK3AEPHA2MAPK13PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7498434-B2 | Two-phase method for the synthesis of selected pyrazolopyrimidines | MALLINCKRODT INC (US) | 2009-03-03 | — | — | US | claimed |
| WO-2006033795-A2 | SUBSTITUTED PYRAZOLO [1, 5-A] PYRIMIDINES FOR INHIBITING ABNORMAL CELL GROWTH | WYETH (US) | 2006-03-30 | — | — | WO | claimed |
| WO-2006033796-A1 | SUBSTITUTED PYRAZOLO [1,5-a] PYRIMIDINES AND PROCESS FOR MAKING SAME | WYETH (US) | 2006-03-30 | — | — | WO | claimed |
| EP-1713808-A1 | TWO-PHASE METHOD FOR THE SYNTHESIS OF SELECTED PYRAZOLOPYRIMIDINES | MALLINCKRODT, INC. (US) | 2006-10-25 | — | — | EP | disclosed |
| WO-2006033795-A2 | SUBSTITUTED PYRAZOLO [1, 5-A] PYRIMIDINES FOR INHIBITING ABNORMAL CELL GROWTH | WYETH (US) | 2006-03-30 | — | — | WO | disclosed |
| WO-2006033796-A1 | SUBSTITUTED PYRAZOLO [1,5-a] PYRIMIDINES AND PROCESS FOR MAKING SAME | WYETH (US) | 2006-03-30 | — | — | WO | disclosed |
| WO-2005070931-A1 | TWO-PHASE METHOD FOR THE SYNTHESIS OF SELECTED PYRAZOLOPYRIMIDINES | MALLINCKRODT INC. (US) | 2005-08-04 | — | — | WO | disclosed |
| US-4654347-A | USEFUL AS ANXIOLYTIC AND ANTIEPILEPTIC AGENTS, SEDATIVE-HYPNOTIC AGENTS AND SKELETAL MUSCLE RELAXANTS | AMERICAN CYANAMID COMPANY (US) | 1987-03-31 | — | — | US | disclosed |