Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 10/20 | 0.52 |
| ▸ | CCND1 | P24385 | 10/20 | 0.52 |
| ▸ | CDK11A | Q9UQ88 | 9/20 | 0.51 |
| ▸ | CCNT1 | O60563 | 8/20 | 0.51 |
| ▸ | CDK9 | P50750 | 8/20 | 0.51 |
| ▸ | CDK6 | Q00534 | 8/20 | 0.51 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.51 |
| ▸ | LTK | P29376 | 1/20 | 0.51 |
| ▸ | CLK2 | P49760 | 1/20 | 0.51 |
| ▸ | GSK3A | P49840 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
| ▸ | CDK7 | P50613 | 1/20 | 0.51 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.51 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.51 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.51 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.51 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.47 |
| ▸ | CDK2 | P24941 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4333612 | 0.91 | CDK4 (0.51) | CDK4CCND1CDK11ACCNT1CDK9 | |
| SCHEMBL4343119 | 0.85 | CDK4 (0.56) | CDK4CCND1CDK11ACCNT1CDK9 | |
| SCHEMBL4333379 | 0.84 | CDK4 (0.56) | CDK4CCND1CDK11ACCNT1CDK9 | |
| SCHEMBL5745076 | 0.83 | CDK4 (0.74) | CDK4CCND1CDK11ACCNT1CDK9 | |
| SCHEMBL4338443 | 0.83 | CDK4 (0.56) | CDK4CCND1CDK11ACCNT1CDK9 | |
| SCHEMBL4331535 | 0.82 | CDK5 (0.47) | CDK4CCND1CDK11ACCNT1CDK9 | |
| SCHEMBL4336027 | 0.81 | CDK4 (0.54) | CDK4CCND1CDK11ACCNT1CDK9 | |
| SCHEMBL4331555 | 0.79 | CDK4 (0.51) | CDK4CCND1CDK11ACCNT1CDK9 | |
| SCHEMBL4342717 | 0.79 | CDK4 (0.57) | CDK4CCND1CDK11ACCNT1CDK9 | |
| SCHEMBL4335185 | 0.79 | CDK4 (0.55) | CDK4CCND1CDK11ACCNT1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740576-B1 | NOVEL PIPERIDINE SUBSTITUTED DIAMINOTHIAZOLES | HOFFMANN LA ROCHE (CH) | 2009-07-01 | — | — | EP | disclosed |