Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 10/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | SENP2 | Q9HC62 | 1/20 | 0.47 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4494795 | 0.89 | GSK3B (0.55) | GSK3BHDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL4503894 | 0.89 | HDAC1 (0.66) | GSK3BHDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL4505671 | 0.89 | HDAC1 (0.63) | GSK3BHDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL4503201 | 0.88 | GSK3B (0.59) | GSK3BHDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL4497400 | 0.88 | GSK3B (0.56) | GSK3BHDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL4488966 | 0.87 | GSK3B (0.57) | GSK3BHDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL4491185 | 0.87 | GSK3B (0.64) | GSK3BHDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL4499827 | 0.86 | GSK3B (0.64) | GSK3BHDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL4495281 | 0.85 | GSK3B (0.55) | GSK3BHDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL4490092 | 0.85 | GSK3B (0.60) | GSK3BHDAC1HDAC2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |