Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.70 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.61 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.61 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.61 |
| ▸ | GSK3B | P49841 | 4/20 | 0.53 |
| ▸ | FGFR4 | P22455 | 4/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.51 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.51 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.51 |
| ▸ | PLK4 | O00444 | 1/20 | 0.50 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.50 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | CDK1 | P06493 | 1/20 | 0.50 |
| ▸ | PIM1 | P11309 | 1/20 | 0.50 |
| ▸ | CDK2 | P24941 | 1/20 | 0.50 |
| ▸ | MARK3 | P27448 | 1/20 | 0.50 |
| ▸ | FLT4 | P35916 | 1/20 | 0.50 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4491427 | 0.91 | HDAC6 (0.58) | HDAC6HDAC1HDAC2HDAC8GSK3B | |
| SCHEMBL4496487 | 0.89 | GSK3B (0.67) | HDAC6HDAC1HDAC2HDAC8GSK3B | |
| SCHEMBL4492534 | 0.88 | GSK3B (0.58) | HDAC6HDAC1HDAC2HDAC8GSK3B | |
| SCHEMBL4559632 | 0.88 | HDAC6 (0.56) | HDAC6HDAC1HDAC2HDAC8GSK3B | |
| SCHEMBL4489306 | 0.86 | HDAC6 (0.57) | HDAC6GSK3BFGFR1FGFR2FGFR3 | |
| SCHEMBL4500068 | 0.85 | HDAC6 (0.55) | HDAC6HDAC1HDAC2HDAC8GSK3B | |
| SCHEMBL4502956 | 0.85 | HDAC6 (0.74) | HDAC6HDAC1HDAC2HDAC8GSK3B | |
| SCHEMBL4495347 | 0.85 | GSK3B (0.65) | HDAC6GSK3BFGFR1FGFR2FGFR3 | |
| SCHEMBL4500708 | 0.85 | GSK3B (0.67) | HDAC6HDAC1HDAC2HDAC8GSK3B | |
| SCHEMBL4487681 | 0.85 | HDAC6 (0.80) | HDAC6HDAC1HDAC2HDAC8GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |