Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 20/20 | 0.51 |
| ▸ | PDE1C | Q14123 | 8/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4500030 | 1.00 | PDE9A (0.51) | PDE9APDE1CHDAC1HDAC2HDAC6 | |
| SCHEMBL4500032 | 0.87 | TYK2 (0.44) | PDE9APDE1C | |
| SCHEMBL13870452 | 0.87 | PDE9A (0.52) | PDE9APDE1CHDAC1HDAC2HDAC6 | |
| SCHEMBL4524011 | 0.85 | PDE9A (0.57) | PDE9APDE1CHDAC1HDAC2HDAC6 | |
| SCHEMBL4512427 | 0.79 | PDE9A (0.51) | PDE9APDE1CHDAC1HDAC2HDAC6 | |
| SCHEMBL4516242 | 0.79 | PDE9A (0.51) | PDE9APDE1CHDAC1HDAC2HDAC6 | |
| SCHEMBL4512418 | 0.79 | PDE9A (0.51) | PDE9APDE1CHDAC1HDAC2HDAC6 | |
| SCHEMBL4510198 | 0.77 | PDE9A (0.56) | PDE9APDE1CHDAC1HDAC2HDAC6 | |
| SCHEMBL4511763 | 0.77 | PDE9A (0.56) | PDE9APDE1CHDAC1HDAC2HDAC6 | |
| SCHEMBL13865753 | 0.76 | PDE9A (0.57) | PDE9APDE1CHDAC1HDAC2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090137549-A1 | Novel compounds useful for the treatment of degenerative & inflamatory diseases | GALAPAGOS NV (BE) | 2009-05-28 | — | — | US | disclosed |
| US-20090137549-A1 | Novel compounds useful for the treatment of degenerative & inflamatory diseases | GALAPAGOS NV (BE) | 2009-05-28 | — | — | US | disclosed |
| WO-2008055959-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS N.V. (BE) | 2008-05-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137549-A1 | Novel compounds useful for the treatment of degenerative & inflamatory diseases | PDE4A, PDE7B, PDE4B | PDE9A 13/4885PDE1C 190/4885HDAC1 869/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.