Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 2/20 | 0.39 |
| ▸ | PLK1 | P53350 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 2/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.35 |
| ▸ | HPSE | Q9Y251 | 2/20 | 0.35 |
| ▸ | PPARG | P37231 | 2/20 | 0.35 |
| ▸ | PPARD | Q03181 | 2/20 | 0.35 |
| ▸ | PPARA | Q07869 | 2/20 | 0.35 |
| ▸ | MET | P08581 | 7/20 | 0.34 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4500851 | 1.00 | LPAR1 (0.39) | LPAR1PLK1ALDH1A1MAPK1FLT3 | |
| SCHEMBL4480808 | 0.95 | TAAR1 (0.37) | LPAR1ALDH1A1MAPK1FLT3BACE1 | |
| SCHEMBL4480805 | 0.95 | TAAR1 (0.37) | LPAR1ALDH1A1MAPK1FLT3BACE1 | |
| SCHEMBL4493725 | 0.94 | PLK1 (0.38) | LPAR1PLK1ALDH1A1MAPK1FLT3 | |
| SCHEMBL4493722 | 0.94 | PLK1 (0.38) | LPAR1PLK1ALDH1A1MAPK1FLT3 | |
| SCHEMBL226975 | 0.93 | PLK1 (0.39) | PLK1ALDH1A1FLT3BACE1NR1H4 | |
| SCHEMBL226974 | 0.93 | PLK1 (0.39) | PLK1ALDH1A1FLT3BACE1NR1H4 | |
| SCHEMBL4493512 | 0.92 | BACE1 (0.40) | LPAR1ALDH1A1MAPK1FLT3BACE1 | |
| SCHEMBL4493517 | 0.92 | BACE1 (0.40) | LPAR1ALDH1A1MAPK1FLT3BACE1 | |
| SCHEMBL4499144 | 0.90 | PLK1 (0.48) | PLK1FLT3NR1H4PDGFRBKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7514468-B2 | Indolinone derivatives substituted in the 6 position, the preparation thereof and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2009-04-07 | — | — | US | disclosed |
| US-20060194813-A1 | Indolinone derivatives substituted in the 6 position, the preparation thereof and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2006-08-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060194813-A1 | Indolinone derivatives substituted in the 6 position, the preparation thereof and their use as pharmaceutical compositions | KDR, FLT1, EGFR | LPAR1 912/4885PLK1 86/4885ALDH1A1 2036/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.