Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | PLK1 | P53350 | 1/20 | 0.37 |
| ▸ | GHSR | Q92847 | 3/20 | 0.37 |
| ▸ | PIM1 | P11309 | 2/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4501589 | 1.00 | SMN1; SMN2 (0.42) | SMN1; SMN2ALDH1A1KDM4ETSHRATM | |
| SCHEMBL4501785 | 0.92 | SMN1; SMN2 (0.43) | SMN1; SMN2ALDH1A1KDM4ETSHRPLK1 | |
| SCHEMBL4501787 | 0.92 | SMN1; SMN2 (0.43) | SMN1; SMN2ALDH1A1KDM4ETSHRPLK1 | |
| SCHEMBL4497385 | 0.91 | SMN1; SMN2 (0.42) | SMN1; SMN2ALDH1A1KDM4ETSHRPLK1 | |
| SCHEMBL4497388 | 0.91 | SMN1; SMN2 (0.42) | SMN1; SMN2ALDH1A1KDM4ETSHRPLK1 | |
| SCHEMBL4485830 | 0.90 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1PLK1GHSRPIM1 | |
| SCHEMBL4504806 | 0.90 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1ATMPLK1GHSR | |
| SCHEMBL4504800 | 0.90 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1ATMPLK1GHSR | |
| SCHEMBL4485831 | 0.90 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1PLK1GHSRPIM1 | |
| SCHEMBL4501911 | 0.90 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1PLK1GHSRPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7514468-B2 | Indolinone derivatives substituted in the 6 position, the preparation thereof and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2009-04-07 | — | — | US | disclosed |
| US-20060194813-A1 | Indolinone derivatives substituted in the 6 position, the preparation thereof and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2006-08-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060194813-A1 | Indolinone derivatives substituted in the 6 position, the preparation thereof and their use as pharmaceutical compositions | KDR, FLT1, EGFR | SMN1; SMN2 4006/4885ALDH1A1 2036/4885KDM4E 1648/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.