Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 5/20 | 0.45 |
| ▸ | RPTOR | Q8N122 | 5/20 | 0.45 |
| ▸ | MLST8 | Q9BVC4 | 5/20 | 0.45 |
| ▸ | PLAT | P00750 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15026243 | 0.85 | MTOR (0.48) | MTORRPTORMLST8PLATHCRTR2 | |
| SCHEMBL39348 | 0.80 | MTOR (0.52) | MTORRPTORMLST8 | |
| SCHEMBL31381 | 0.79 | MTOR (0.56) | MTORRPTORMLST8HCRTR2 | |
| SCHEMBL45632 | 0.77 | MTOR (0.42) | MTORRPTORMLST8 | |
| SCHEMBL45689 | 0.77 | MTOR (0.47) | MTORRPTORMLST8 | |
| SCHEMBL45585 | 0.77 | MTOR (0.46) | MTORRPTORMLST8HCRTR2 | |
| SCHEMBL45584 | 0.77 | MTOR (0.41) | MTORRPTORMLST8HCRTR2 | |
| SCHEMBL45734 | 0.76 | MTOR (0.47) | MTORRPTORMLST8 | |
| SCHEMBL45630 | 0.76 | MTOR (0.46) | MTORRPTORMLST8 | |
| SCHEMBL31031 | 0.75 | MTOR (0.45) | MTORRPTORMLST8PLAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2608668-B1 | FUSED TRICYCLIC INHIBITORS OF MAMMALIAN TARGET OF RAPAMYCIN | MERCK SHARP & DOHME (US) | 2016-06-01 | — | — | EP | disclosed |
| WO-2012027234-A1 | FUSED TRICYCLIC INHIBITORS OF MAMMALIAN TARGET OF RAPAMYCIN | SCHERING CORPORATION (US) | 2012-03-01 | — | — | WO | disclosed |