Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 15/20 | 0.65 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.60 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.60 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4494630 | 0.92 | HDAC1 (0.58) | GSK3BHDAC1HDAC2HDAC8CYP1A2 | |
| SCHEMBL4484179 | 0.91 | GSK3B (0.59) | GSK3BHDAC1HDAC2HDAC8CYP1A2 | |
| SCHEMBL4484182 | 0.91 | HDAC1 (0.57) | GSK3BHDAC1HDAC2HDAC8CYP1A2 | |
| SCHEMBL4491185 | 0.91 | GSK3B (0.64) | GSK3BHDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL4499827 | 0.90 | GSK3B (0.64) | GSK3BHDAC1HDAC2HDAC8CYP1A2 | |
| SCHEMBL4489278 | 0.89 | GSK3B (0.52) | GSK3BHDAC1HDAC2HDAC8CYP1A2 | |
| SCHEMBL4492733 | 0.89 | GSK3B (0.72) | GSK3BHDAC1HDAC2HDAC8CYP1A2 | |
| SCHEMBL4486772 | 0.88 | HDAC1 (0.66) | GSK3BHDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL4491275 | 0.87 | GSK3B (0.68) | GSK3BHDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL4488966 | 0.87 | GSK3B (0.57) | GSK3BHDAC1HDAC2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |