Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.42 |
| ▸ | GHSR | Q92847 | 3/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
| ▸ | MELK | Q14680 | 7/20 | 0.38 |
| ▸ | PIM1 | P11309 | 2/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.37 |
| ▸ | PRKAB2 | O43741 | 3/20 | 0.37 |
| ▸ | NUAK1 | O60285 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | PRKAG1 | P54619 | 3/20 | 0.37 |
| ▸ | PRKAA2 | P54646 | 3/20 | 0.37 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.37 |
| ▸ | CAMKK2 | Q96RR4 | 3/20 | 0.37 |
| ▸ | PRKAG3 | Q9UGI9 | 3/20 | 0.37 |
| ▸ | PRKAG2 | Q9UGJ0 | 3/20 | 0.37 |
| ▸ | PRKAB1 | Q9Y478 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4503071 | 1.00 | DRD4 (0.43) | DRD4SMN1; SMN2AAK1GHSRPLK1 | |
| SCHEMBL4485411 | 0.92 | AAK1 (0.46) | DRD4SMN1; SMN2AAK1GHSRTACR1 | |
| SCHEMBL4485414 | 0.92 | AAK1 (0.46) | DRD4SMN1; SMN2AAK1GHSRTACR1 | |
| SCHEMBL4492354 | 0.89 | AAK1 (0.44) | DRD4SMN1; SMN2AAK1GHSRTACR1 | |
| SCHEMBL4492351 | 0.89 | AAK1 (0.44) | DRD4SMN1; SMN2AAK1GHSRTACR1 | |
| SCHEMBL4481631 | 0.89 | AAK1 (0.41) | AAK1MELKCHEK1PRKAB2NUAK1 | |
| SCHEMBL4481634 | 0.89 | AAK1 (0.41) | AAK1MELKCHEK1PRKAB2NUAK1 | |
| SCHEMBL4494115 | 0.89 | SMN1; SMN2 (0.42) | DRD4SMN1; SMN2AAK1GHSRPLK1 | |
| SCHEMBL4505075 | 0.89 | SMN1; SMN2 (0.42) | DRD4SMN1; SMN2AAK1GHSRPLK1 | |
| SCHEMBL4494118 | 0.89 | SMN1; SMN2 (0.42) | DRD4SMN1; SMN2AAK1GHSRPLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7514468-B2 | Indolinone derivatives substituted in the 6 position, the preparation thereof and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2009-04-07 | — | — | US | disclosed |
| US-20060194813-A1 | Indolinone derivatives substituted in the 6 position, the preparation thereof and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2006-08-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060194813-A1 | Indolinone derivatives substituted in the 6 position, the preparation thereof and their use as pharmaceutical compositions | KDR, FLT1, EGFR | DRD4 1051/4885SMN1; SMN2 4006/4885AAK1 1080/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.